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Letm2 leucine zipper and EF-hand containing transmembrane protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361169, updated on 11-Apr-2024

Summary

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Official Symbol
Letm2provided by RGD
Official Full Name
leucine zipper and EF-hand containing transmembrane protein 2provided by RGD
Primary source
RGD:1311220
See related
Ensembl:ENSRNOG00000026180 AllianceGenome:RGD:1311220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LETM2S
Summary
Predicted to enable ribosome binding activity. Predicted to be involved in cellular metal ion homeostasis. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Orthologous to human LETM2 (leucine zipper and EF-hand containing transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 123.1), Thymus (RPKM 39.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73171768..73192336)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66464958..66489640)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71241335..71261841)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482516 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene Fibroblast growth factor receptor 1 Neighboring gene uncharacterized LOC120097430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. Tamai S, et al. J Cell Sci, 2008 Aug 1. PMID 18628306
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LETM1 domain-containing protein LETM2, mitochondrial
Names
LETM1 and EF-hand domain-containing protein 2
leucine zipper-, EF-hand motif- containing transmembrane protein 2
leucine zipper-, EF-hand motif- containing transmembrane protein 2S
leucine zipper-EF-hand containing transmembrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012158.1 → NP_001012158.1  LETM1 domain-containing protein LETM2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001012158.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087079
    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5
    UniProtKB/TrEMBL
    A0A8I5ZTW7
    Related
    ENSRNOP00000081903.1, ENSRNOT00000118537.1
    Conserved Domains (1) summary
    pfam07766
    Location:121 → 387
    LETM1; LETM1-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    73171768..73192336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275559.1 → XP_063131629.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

  2. XM_063275560.1 → XP_063131630.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X7

  3. XM_063275570.1 → XP_063131640.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X10

  4. XM_063275525.1 → XP_063131595.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  5. XM_063275563.1 → XP_063131633.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

  6. XM_063275531.1 → XP_063131601.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

  7. XM_063275542.1 → XP_063131612.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  8. XM_063275567.1 → XP_063131637.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

  9. XM_063275536.1 → XP_063131606.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  10. XM_063275548.1 → XP_063131618.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  11. XM_063275544.1 → XP_063131614.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  12. XM_063275535.1 → XP_063131605.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  13. XM_063275547.1 → XP_063131617.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  14. XM_063275554.1 → XP_063131624.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  15. XM_063275538.1 → XP_063131608.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  16. XM_063275546.1 → XP_063131616.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  17. XM_063275533.1 → XP_063131603.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  18. XM_063275520.1 → XP_063131590.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  19. XM_063275529.1 → XP_063131599.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  20. XM_063275552.1 → XP_063131622.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  21. XM_063275549.1 → XP_063131619.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  22. XM_063275543.1 → XP_063131613.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  23. XM_063275537.1 → XP_063131607.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  24. XM_063275526.1 → XP_063131596.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  25. XM_063275564.1 → XP_063131634.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

  26. XM_063275558.1 → XP_063131628.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

  27. XM_063275568.1 → XP_063131638.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

  28. XM_063275532.1 → XP_063131602.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

  29. XM_063275556.1 → XP_063131626.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X5

  30. XM_063275523.1 → XP_063131593.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  31. XM_063275566.1 → XP_063131636.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

  32. XM_063275528.1 → XP_063131598.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  33. XM_039094661.2 → XP_038950589.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9, A6IW13
    Related
    ENSRNOP00000083182.1
    Conserved Domains (1) summary
    pfam07766
    Location:121 → 387
    LETM1; LETM1-like protein

  34. XM_063275555.1 → XP_063131625.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X5

  35. XM_039094664.2 → XP_038950592.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6IW13, F1LP77
    Related
    ENSRNOP00000062009.4
    Conserved Domains (1) summary
    pfam07766
    Location:121 → 387
    LETM1; LETM1-like protein

  36. XM_039094665.2 → XP_038950593.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5
    UniProtKB/TrEMBL
    A0A8I5ZTW7
    Conserved Domains (1) summary
    pfam07766
    Location:121 → 387
    LETM1; LETM1-like protein

  37. XM_063275561.1 → XP_063131631.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

  38. XM_063275557.1 → XP_063131627.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

  39. XM_063275534.1 → XP_063131604.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  40. XM_063275522.1 → XP_063131592.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  41. XM_063275545.1 → XP_063131615.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  42. XM_063275539.1 → XP_063131609.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    F1LP77

  43. XM_063275524.1 → XP_063131594.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  44. XM_063275550.1 → XP_063131620.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  45. XM_063275565.1 → XP_063131635.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

  46. XM_063275527.1 → XP_063131597.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYR9

  47. XM_063275553.1 → XP_063131623.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    UniProtKB/Swiss-Prot
    A7VL16, Q5PQQ5

  48. XM_039094662.2 → XP_038950590.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6IW13
    Conserved Domains (1) summary
    pfam07766
    Location:121 → 387
    LETM1; LETM1-like protein

  49. XM_063275569.1 → XP_063131639.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X10

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQQ5.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ5

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