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ILK integrin linked kinase [ Homo sapiens (human) ]

Gene ID: 3611, updated on 3-Apr-2024

Summary

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Official Symbol
ILKprovided by HGNC
Official Full Name
integrin linked kinaseprovided by HGNC
Primary source
HGNC:HGNC:6040
See related
Ensembl:ENSG00000166333 MIM:602366; AllianceGenome:HGNC:6040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P59; ILK-1; ILK-2; p59ILK; HEL-S-28
Summary
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ILK in Genome Data Viewer
Location:
11p15.4
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6603774..6610870)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6662246..6669338)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6625004..6632101)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene dynein heavy chain domain 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6589123-6589980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6592335-6592842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6607422-6608410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6608411-6609399 Neighboring gene Sharpr-MPRA regulatory region 2811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6624079-6624620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4347 Neighboring gene Sharpr-MPRA regulatory region 730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6632062-6632650 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6632651-6633238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3106 Neighboring gene ribosomal RNA processing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4350 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4352 Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6662561-6663130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6668387-6668887

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis. Huang Q, et al. J Extracell Vesicles, 2023 Jul. PMID 37357686, Free PMC Article
  2. Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK. Wang Y, et al. ACS Biomater Sci Eng, 2023 Feb 13. PMID 36732940
  3. The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation. Petrou IG, et al. Cells, 2022 Oct 29. PMID 36359821, Free PMC Article
  4. Integrin-linked kinase (ILK): the known vs. the unknown and perspectives. Górska A, et al. Cell Mol Life Sci, 2022 Jan 28. PMID 35089438, Free PMC Article
  5. Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors. Beetham H, et al. Cancer Res, 2022 Feb 15. PMID 34921014, Free PMC Article

See all (367) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
    Title: Integrin-linked kinase expression in myeloid cells promotes colon tumorigenesis.
  2. Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.
    Title: Extracellular vesicle-packaged ILK from mesothelial cells promotes fibroblast activation in peritoneal fibrosis.
  3. Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK.
    Title: Substrate Stiffness Regulates the Proliferation and Apoptosis of Periodontal Ligament Cells through Integrin-Linked Kinase ILK.
  4. The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation.
    Title: The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation.
  5. Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
    Title: Identification and validation of EMT-immune-related prognostic biomarkers CDKN2A, CMTM8 and ILK in colon cancer.
  6. Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
    Title: Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
  7. Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
    Title: Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors.
  8. Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis.
    Title: Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis.
  9. Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.
    Title: Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.
  10. Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
    Title: Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
Submit: New GeneRIF Correction See all GeneRIFs (243)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686F1765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast migration IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
  
involved_in neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet aggregation HMP PubMed 
involved_in positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrin-linked protein kinase
Names
59 kDa serine/threonine-protein kinase
beta-integrin-linked kinase
epididymis secretory protein Li 28
integrin-linked kinase-2
NP_001014794.1
NP_001014795.1
NP_001265370.1
NP_001265371.1
NP_004508.1
XP_005252961.1
XP_011518367.1
XP_024304266.1
XP_024304267.1
XP_047282841.1
XP_054224646.1
XP_054224647.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029702.1 RefSeqGene

    Range
    4975..12142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

mRNA and Protein(s)

  1. NM_001014794.3 → NP_001014794.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001014794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC001554, DC380243, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
    UniProtKB/TrEMBL
    A0A0A0MTH3, V9HWF0
    Related
    ENSP00000403487.2, ENST00000420936.6
    Conserved Domains (4) summary
    cd14057
    Location:197 → 449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 54
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:38 → 124
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001014795.3 → NP_001014795.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001014795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AC091564, CR749220, DC379936, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
    UniProtKB/TrEMBL
    A0A0A0MTH3, V9HWF0
    Related
    ENSP00000379975.2, ENST00000396751.6
    Conserved Domains (4) summary
    cd14057
    Location:197 → 449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 54
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:38 → 124
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001278441.2 → NP_001265370.1  integrin-linked protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001265370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC091564, AK296628, DC380243, HY257434, U40282
    Consensus CDS
    CCDS60712.1
    UniProtKB/TrEMBL
    A0A0A0MTH3
    Related
    ENSP00000435323.1, ENST00000528995.5
    Conserved Domains (4) summary
    cd14057
    Location:144 → 388
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 54
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:38 → 117
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_001278442.2 → NP_001265371.1  integrin-linked protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001265371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK293474
    Consensus CDS
    CCDS60713.1
    UniProtKB/Swiss-Prot
    Q13418
    Related
    ENSP00000434492.2, ENST00000532063.5
    Conserved Domains (1) summary
    cd14057
    Location:63 → 315
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase

  5. NM_004517.4 → NP_004508.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_004508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    DC380243, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
    UniProtKB/TrEMBL
    A0A0A0MTH3, V9HWF0
    Related
    ENSP00000299421.4, ENST00000299421.9
    Conserved Domains (4) summary
    cd14057
    Location:197 → 449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 54
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:38 → 124
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6603774..6610870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520065.2 → XP_011518367.1  integrin-linked protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011518367.1

    UniProtKB/Swiss-Prot
    B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
    UniProtKB/TrEMBL
    A0A0A0MTH3, V9HWF0
    Conserved Domains (4) summary
    cd14057
    Location:197 → 449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 54
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:38 → 124
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_047426885.1 → XP_047282841.1  integrin-linked protein kinase isoform X3

  3. XM_005252904.6 → XP_005252961.1  integrin-linked protein kinase isoform X1

    See identical proteins and their annotated locations for XP_005252961.1

    UniProtKB/Swiss-Prot
    B7Z1I0, B7Z418, D3DQU0, P57043, Q13418, Q68DZ3
    UniProtKB/TrEMBL
    A0A0A0MTH3, V9HWF0
    Conserved Domains (4) summary
    cd14057
    Location:197 → 449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 54
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:38 → 124
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_024448499.2 → XP_024304267.1  integrin-linked protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A0A0MTH3
    Conserved Domains (3) summary
    cd14057
    Location:146 → 398
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:15 → 46
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2 → 73
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_024448498.2 → XP_024304266.1  integrin-linked protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A0A0MTH3
    Conserved Domains (3) summary
    cd14057
    Location:146 → 398
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:15 → 46
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:2 → 73
    Ank_2; Ankyrin repeats (3 copies)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6662246..6669338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368672.1 → XP_054224647.1  integrin-linked protein kinase isoform X2

  2. XM_054368671.1 → XP_054224646.1  integrin-linked protein kinase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13418.2 GenPept UniProtKB/Swiss-Prot:Q13418

Gene LinkOut

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