Pxn paxillin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pxnprovided by RGD
Full Name: paxillinprovided by RGD
Primary source: RGD:1305759
See related: Ensembl:ENSRNOG00000001149 AllianceGenome:RGD:1305759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables integrin binding activity and protein kinase binding activity. Involved in response to peptide. Located in focal adhesion. Orthologous to human PXN (paxillin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 120.4), Lung (RPKM 104.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (46721546..46768706, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41060791..41107952, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (46797953..46845107, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data demonstrate PTP-PEST expression in adrenal ZF and its regulation by ACTH/PKA and also suggest an ACTH-induced PTP-PEST-paxillin interaction
Title: ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.
These findings indicated that down-regulation of ANXA2 by siRNA results in the inhibition of the aberrant dysregulation of paxillin and migration of PASMCs, which suggesting a potential therapeutic effect on HPS-associated PVR.
Title: Annexin A2 inhibits the migration of PASMCs stimulated with HPS rat serum by down-regulating the expression of paxillin.
downregulation of paxillin results in inhibition of dysregulation of cytoskeletal proteins and proliferation of pulmonary artery smooth muscle cells, suggesting a potential therapeutic effect on pulmonary vascular remodelling in Hepatopulmonary syndrome
Title: Paxillin suppresses the proliferation of HPS rat serum treated PASMCs by up-regulating the expression of cytoskeletal proteins.
The dynamic expression of paxillin in rat pancreas from different stages indicates that paxillin might be involved in some aspects of pancreatic development.
Title: Expression and localization of paxillin in rat pancreas during development.
Talin and paxillin showed a major distributional change between different hormone regimes, estrogen and progesterone
Title: Ovarian hormones regulate expression of the focal adhesion proteins, talin and paxillin, in rat uterine luminal but not glandular epithelial cells.
Data show that the migration associated control of JNK by aPKCs determines JNK phosphorylation of the plasma membrane substrate paxillin.
Title: An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.
Data show that CXCL8 stimulation leads to paxillin phosphorylation in normal neutrophils, and that both CXCL8 receptors (CXCR1 and CXCR2) mediate CXCL8-induced paxillin phosphorylation.
Title: Cell migration to the chemokine CXCL8: paxillin is activated and regulates adhesion and cell motility.
Uterine epithelial cells are less adherent to the underlying basal lamina due to the disassembly of talin and paxillin from focal adhesions, facilitating removal of these cells at the time of implantation.
Title: Focal adhesions disassemble during early pregnancy in rat uterine epithelial cells.
Paxillin associated with clustered IgE-Fc epsilonRI has a net positive effect on Fc epsilonRI signaling.
Title: Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays.
Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin.
Title: Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S1348 (e-PCR), detects polymorphism
- UniSTS:24193

Pxn (e-PCR), detects polymorphism
- UniSTS:256488

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BH4 domain binding	ISO Inferred from Sequence Orthology more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neuropilin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables vinculin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in response to peptide	IPI Inferred from Physical Interaction more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paxillin

Names: inverted formin-2-like; myocardial ischemic preconditioning associated protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401037.1 → NP_001387966.1 paxillin isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

F7FID5

Related

ENSRNOP00000061647.2, ENSRNOT00000064115.4
NM_001401038.1 → NP_001387967.1 paxillin isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

Q1EG89

Related

ENSRNOP00000043928.3, ENSRNOT00000047466.4
NM_001408855.1 → NP_001395784.1 paxillin isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I6AAE7

Related

ENSRNOP00000089712.1, ENSRNOT00000105395.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

46721546..46768706 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271540.1 → XP_063127610.1 paxillin isoform X4
XM_063271543.1 → XP_063127613.1 paxillin isoform X9

UniProtKB/Swiss-Prot

Q66H76
XM_039089607.2 → XP_038945535.1 paxillin isoform X5

Conserved Domains (5) summary

cd09338
Location:810 → 862

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:751 → 802

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:869 → 920

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:692 → 744

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:1 → 120

Paxillin; Paxillin family
XM_039089603.2 → XP_038945531.1 paxillin isoform X2

Conserved Domains (5) summary

cd09338
Location:1001 → 1053

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:942 → 993

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:1060 → 1111

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:883 → 935

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:112 → 311

Paxillin; Paxillin family
XM_039089602.2 → XP_038945530.1 paxillin isoform X1

Conserved Domains (5) summary

cd09338
Location:1010 → 1062

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:951 → 1002

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:1069 → 1120

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:892 → 944

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:121 → 320

Paxillin; Paxillin family
XM_039089606.2 → XP_038945534.1 paxillin isoform X3

Conserved Domains (5) summary

cd09338
Location:906 → 958

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:847 → 898

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:965 → 1016

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:788 → 840

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:121 → 320

Paxillin; Paxillin family
XM_039089610.2 → XP_038945538.1 paxillin isoform X7

UniProtKB/TrEMBL

A0A8I6AJT3

Related

ENSRNOP00000081906.1

Conserved Domains (5) summary

cd09338
Location:509 → 561

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:450 → 501

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:568 → 619

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:391 → 443

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:121 → 320

Paxillin; Paxillin family
XM_063271542.1 → XP_063127612.1 paxillin isoform X8

UniProtKB/TrEMBL

A0A8I5ZUE4
XM_039089608.2 → XP_038945536.2 paxillin isoform X6

UniProtKB/TrEMBL

A6J1T6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001012147.1: Suppressed sequence

Description

NM_001012147.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.