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Nt5c3b 5'-nucleotidase, cytosolic IIIB [ Rattus norvegicus (Norway rat) ]

Gene ID: 360629, updated on 5-Mar-2024

Summary

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Official Symbol
Nt5c3bprovided by RGD
Official Full Name
5'-nucleotidase, cytosolic IIIBprovided by RGD
Primary source
RGD:1359229
See related
Ensembl:ENSRNOG00000016475 AllianceGenome:RGD:1359229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nt5c3l
Summary
Predicted to enable 5'-nucleotidase activity; magnesium ion binding activity; and nucleotide binding activity. Predicted to be involved in dephosphorylation and nucleotide metabolic process. Predicted to be active in cytoplasm. Orthologous to human NT5C3B (5'-nucleotidase, cytosolic IIIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 108.1), Adrenal (RPKM 91.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85859509..85876731, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85358483..85376340, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88338700..88356538, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480874 Neighboring gene prolyl 3-hydroxylase family member 4 Neighboring gene FKBP prolyl isomerase 10 Neighboring gene kelch-like family member 10 Neighboring gene kelch-like family member 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93839

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
7-methylguanosine phosphate-specific 5'-nucleotidase
Names
5'-nucleotidase, cytosolic III-like
7-methylguanosine nucleotidase
N(7)-methylguanylate 5'-phosphatase
cN-III-like protein
cytosolic 5'-nucleotidase 3B
cytosolic 5'-nucleotidase III-like protein
cytosolic 5-nucleotidase III-like protein-like
NP_001007724.2
XP_008766306.1
XP_017452886.1
XP_063125502.1
XP_063125503.1
XP_063125504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007723.2 → NP_001007724.2  7-methylguanosine phosphate-specific 5'-nucleotidase

    See identical proteins and their annotated locations for NP_001007724.2

    Status: VALIDATED

    Source sequence(s)
    AW527524, BC078963
    UniProtKB/Swiss-Prot
    F8WG43, Q6AYP7
    Related
    ENSRNOP00000022430.3, ENSRNOT00000022430.7
    Conserved Domains (1) summary
    pfam05822
    Location:44 → 289
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    85859509..85876731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768084.4 → XP_008766306.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X4

    Conserved Domains (1) summary
    pfam05822
    Location:44 → 256
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  2. XM_017597397.3 → XP_017452886.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X2

    UniProtKB/Swiss-Prot
    F8WG43, Q6AYP7
    Conserved Domains (1) summary
    pfam05822
    Location:44 → 289
    UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

  3. XM_063269432.1 → XP_063125502.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X1

  4. XM_063269434.1 → XP_063125504.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X5

  5. XM_063269433.1 → XP_063125503.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYP7.2 GenPept UniProtKB/Swiss-Prot:Q6AYP7

Gene LinkOut

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Chemical Information
Molecular Biology Databases
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