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Rnf167 ring finger protein 167 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360554, updated on 11-Apr-2024

Summary

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Official Symbol
Rnf167provided by RGD
Official Full Name
ring finger protein 167provided by RGD
Primary source
RGD:1305972
See related
Ensembl:ENSRNOG00000003879 AllianceGenome:RGD:1305972
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305972
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of cell cycle; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in endomembrane system. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human RNF167 (ring finger protein 167). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 358.0), Spleen (RPKM 279.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55859254..55863546)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55360603..55364927)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57268331..57272667)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene solute carrier family 25 member 11 Neighboring gene profilin 1 Neighboring gene enolase 3 Neighboring gene sperm associated antigen 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Yamada HY, et al. Oncogene, 2006 Mar 2. PMID 16314844, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94514

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leucine starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in organelle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K29-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endolysosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endolysosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF167
Names
RING-type E3 ubiquitin transferase RNF167
NP_001008362.1
XP_006246812.1
XP_038942250.1
XP_063125409.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008361.1 → NP_001008362.1  E3 ubiquitin-protein ligase RNF167 precursor

    See identical proteins and their annotated locations for NP_001008362.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083670
    UniProtKB/Swiss-Prot
    Q5XIL0
    UniProtKB/TrEMBL
    A6HG77, A6HG78
    Related
    ENSRNOP00000005242.4, ENSRNOT00000005242.5
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55859254..55863546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246750.5 → XP_006246812.1  E3 ubiquitin-protein ligase RNF167 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AG57
    Related
    ENSRNOP00000087224.1
    Conserved Domains (2) summary
    cd02123
    Location:1 → 135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193 → 238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  2. XM_039086322.2 → XP_038942250.1  E3 ubiquitin-protein ligase RNF167 isoform X2

    UniProtKB/TrEMBL
    A6HG79
    Conserved Domains (3) summary
    cd00162
    Location:109 → 150
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl28883
    Location:1 → 49
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
    cl17238
    Location:107 → 152
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_063269339.1 → XP_063125409.1  E3 ubiquitin-protein ligase RNF167 isoform X2

    UniProtKB/TrEMBL
    A6HG79
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIL0.1 GenPept UniProtKB/Swiss-Prot:Q5XIL0

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