Plscr3 phospholipid scramblase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plscr3provided by RGD
Official Full Name: phospholipid scramblase 3provided by RGD
Primary source: RGD:1307016
See related: Ensembl:ENSRNOG00000027914 AllianceGenome:RGD:1307016
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pls3
Summary: Enables calcium ion binding activity and phospholipid scramblase activity. Predicted to be involved in several processes, including cardiolipin biosynthetic process; plasma membrane phospholipid scrambling; and regulation of release of cytochrome c from mitochondria. Predicted to act upstream of or within cellular response to lipopolysaccharide; cholesterol homeostasis; and glucose homeostasis. Located in mitochondrial inner membrane. Colocalizes with mitochondrion. Orthologous to human PLSCR3 (phospholipid scramblase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 56.9), Heart (RPKM 42.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55064349..55070120)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54566556..54573240)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56452632..56458390)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLSCR3, via its C-terminal transmembrane domain, participates in the bidirectional movement of phospholipids within the inner membrane of mitochondria.
Title: Topological characterization of the mitochondrial phospholipid scramblase 3.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables lead ion binding	IEA Inferred from Electronic Annotation more info
enables lead ion binding	ISO Inferred from Sequence Orthology more info
enables lead ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables mercury ion binding	IEA Inferred from Electronic Annotation more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid scramblase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid scramblase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid scramblase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane phospholipid scrambling	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipid scramblase 3

Names: PL scramblase 3; ca(2+)-dependent phospholipid scramblase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012139.2 → NP_001012139.1 phospholipid scramblase 3

See identical proteins and their annotated locations for NP_001012139.1

Status: PROVISIONAL

Source sequence(s)

BC098055

UniProtKB/Swiss-Prot

Q4V7A3, Q6QBQ4

UniProtKB/TrEMBL

A0A8I5YBZ8

Related

ENSRNOP00000035566.5, ENSRNOT00000031640.5

Conserved Domains (1) summary

pfam03803
Location:73 → 285

Scramblase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55064349..55070120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086319.2 → XP_038942247.1 phospholipid scramblase 3 isoform X1

UniProtKB/Swiss-Prot

Q4V7A3, Q6QBQ4

UniProtKB/TrEMBL

A0A8I5YBZ8

Conserved Domains (1) summary

pfam03803
Location:73 → 285

Scramblase