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Zranb1 zinc finger, RAN-binding domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 360216, updated on 21-Apr-2024

Summary

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Official Symbol
Zranb1provided by MGI
Official Full Name
zinc finger, RAN-binding domain containing 1provided by MGI
Primary source
MGI:MGI:106441
See related
Ensembl:ENSMUSG00000030967 AllianceGenome:MGI:106441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1956; Trabid; D7Wsu87e; 9330160G10Rik
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including positive regulation of Wnt signaling pathway; protein deubiquitination; and regulation of cell morphogenesis. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; and neural retina. Orthologous to human ZRANB1 (zinc finger RANBP2-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.0), testis adult (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 76.32 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (132532905..132588127)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132931176..132986398)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500002F19 gene Neighboring gene predicted gene, 46003 Neighboring gene predicted gene 45502 Neighboring gene STARR-positive B cell enhancer ABC_E3759 Neighboring gene RIKEN cDNA 4932437C15 gene Neighboring gene STARR-seq mESC enhancer starr_20308 Neighboring gene C-terminal binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_20317 Neighboring gene STARR-seq mESC enhancer starr_20324 Neighboring gene STARR-seq mESC enhancer starr_20325 Neighboring gene predicted gene, 35364

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation. Chen YH, et al. Nat Commun, 2023 May 26. PMID 37237031, Free PMC Article
  2. Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis. Tamura A, et al. Biochem Biophys Res Commun, 2022 Nov 5. PMID 36087511
  3. Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Jin J, et al. Nat Immunol, 2016 Mar. PMID 26808229, Free PMC Article
  4. Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. Somma G, et al. J Assoc Res Otolaryngol, 2012 Jun. PMID 22383091, Free PMC Article
  5. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Tran H, et al. Genes Dev, 2008 Feb 15. PMID 18281465, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation.
    Title: TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation.
  2. Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.
    Title: Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.
  3. Trabid regulates inflammatory T cell responses via facilitation of histone modifications at the promoters of Il12 and Il23, which involved deubiqutination and stabilization of the histone demethylase Jmjd2d.
    Title: Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K29-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K29-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K33-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K33-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin thioesterase Zranb1
Names
TRAF-binding protein
zinc finger Ran-binding domain-containing protein 1
NP_001349127.1
NP_001349128.1
NP_997185.1
XP_006508032.1
XP_011240139.1
XP_036009086.1
XP_036009087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362198.2 → NP_001349127.1  ubiquitin thioesterase Zranb1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806
    Consensus CDS
    CCDS90343.1
    UniProtKB/TrEMBL
    A0A1L1SQ24
    Related
    ENSMUSP00000148867.2, ENSMUST00000215716.2
    Conserved Domains (4) summary
    smart00547
    Location:178 → 201
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:114 → 133
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:464 → 612
    OTU; OTU-like cysteine protease
    pfam18418
    Location:272 → 367
    AnkUBD; Ankyrin ubiquitin-binding domain

  2. NM_001362199.2 → NP_001349128.1  ubiquitin thioesterase Zranb1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806
    Consensus CDS
    CCDS90343.1
    UniProtKB/TrEMBL
    A0A1L1SQ24
    Conserved Domains (4) summary
    smart00547
    Location:178 → 201
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:114 → 133
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:464 → 612
    OTU; OTU-like cysteine protease
    pfam18418
    Location:272 → 367
    AnkUBD; Ankyrin ubiquitin-binding domain

  3. NM_207302.3 → NP_997185.1  ubiquitin thioesterase Zranb1 isoform 1

    See identical proteins and their annotated locations for NP_997185.1

    Status: VALIDATED

    Source sequence(s)
    AC119806
    Consensus CDS
    CCDS21929.1
    UniProtKB/Swiss-Prot
    Q7M760
    Related
    ENSMUSP00000101763.2, ENSMUST00000106157.8
    Conserved Domains (4) summary
    smart00547
    Location:152 → 175
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:88 → 107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:438 → 586
    OTU; OTU-like cysteine protease
    pfam18418
    Location:246 → 341
    AnkUBD; Ankyrin ubiquitin-binding domain

RNA

  1. NR_155454.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119806

  2. NR_163812.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119806

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    132532905..132588127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241837.4 → XP_011240139.1  ubiquitin thioesterase Zranb1 isoform X2

    See identical proteins and their annotated locations for XP_011240139.1

    Conserved Domains (1) summary
    pfam02338
    Location:112 → 260
    OTU; OTU-like cysteine protease

  2. XM_036153194.1 → XP_036009087.1  ubiquitin thioesterase Zranb1 isoform X2

    Conserved Domains (1) summary
    pfam02338
    Location:112 → 260
    OTU; OTU-like cysteine protease

  3. XM_036153193.1 → XP_036009086.1  ubiquitin thioesterase Zranb1 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GQZ6
    Related
    ENSMUSP00000147317.2, ENSMUST00000210507.2
    Conserved Domains (3) summary
    smart00547
    Location:178 → 201
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:114 → 133
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam18418
    Location:272 → 361
    AnkUBD; Ankyrin ubiquitin-binding domain

  4. XM_006507969.4 → XP_006508032.1  ubiquitin thioesterase Zranb1 isoform X2

    See identical proteins and their annotated locations for XP_006508032.1

    Conserved Domains (1) summary
    pfam02338
    Location:112 → 260
    OTU; OTU-like cysteine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7M760.1 GenPept UniProtKB/Swiss-Prot:Q7M760

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