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acs-2 AMP-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3565680, updated on 25-Apr-2024

Summary

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Gene symbol
acs-2
Gene description
AMP-binding domain-containing protein
Primary source
WormBase:WBGene00009221
Locus tag
CELE_F28F8.2
See related
AllianceGenome:WB:WBGene00009221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (15567394..15569897)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AcetylCholine Receptor Neighboring gene tRNA-His Neighboring gene ncRNA Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection. Dasgupta M, et al. Infect Immun, 2020 Jul 21. PMID 32482643, Free PMC Article
  2. Proanthocyanidin trimer gallate modulates lipid deposition and fatty acid desaturation in Caenorhabditis elegans. Nie Y, et al. FASEB J, 2017 Nov. PMID 28760744
  3. Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity. Zuryn S, et al. Mech Ageing Dev, 2010 Sep. PMID 20688098
  4. The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. Liang B, et al. PLoS One, 2010 Mar 25. PMID 20360843, Free PMC Article
  5. Quantum dots increased fat storage in intestine of Caenorhabditis elegans by influencing molecular basis for fatty acid metabolism. Wu Q, et al. Nanomedicine, 2016 Jul. PMID 26956412

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
    Title: NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables medium-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AMP-binding domain-containing protein
NP_506869.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15567394..15569897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074468.6 → NP_506869.1  AMP-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18693
    Conserved Domains (2) summary
    cd05917
    Location:244 → 595
    FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
    PRK08315
    Location:46 → 609
    PRK08315; AMP-binding domain protein; Validated
Nucleotide Protein
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