IGLC6 immunoglobulin lambda constant 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IGLC6provided by HGNC
Official Full Name: immunoglobulin lambda constant 6provided by HGNC
Primary source: HGNC:HGNC:5860
See related: Ensembl:ENSG00000222037 IMGT/GENE-DB:IGLC6; AllianceGenome:HGNC:5860
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IGLC
Summary: Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 22q11.22

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (22919535..22919858)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (23342445..23342768)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (23261707..23262030)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

Ig lambda-6 chain C region
immunoglobulin lambda constant 6 (Kern+Oz- marker)
immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)
immunoglobulin lambda constant region 6 (Kern+ Oz- marker)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in adaptive immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of IgA immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgD immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgE immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgG immunoglobulin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IgG immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
part_of IgM immunoglobulin complex	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.