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prx-11 Peroxisomal biogenesis factor 11 [ Caenorhabditis elegans ]

Gene ID: 353387, updated on 23-Nov-2023

Summary

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Gene symbol
prx-11
Gene description
Peroxisomal biogenesis factor 11
Primary source
WormBase:WBGene00004196
Locus tag
CELE_C47B2.8
See related
AllianceGenome:WB:WBGene00004196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be intrinsic component of peroxisomal membrane. Predicted to be active in peroxisomal membrane. Is expressed in head mesodermal cell; hypodermis; intestine; and rectal gland cell. Orthologous to human PEX11G (peroxisomal biogenesis factor 11 gamma). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See prx-11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_003279.8 (12971615..12972259)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Proteasome subunit beta Neighboring gene Eukaryotic translation initiation factor 6 Neighboring gene UDP-glucose 4-epimerase Neighboring gene Tr-type G domain-containing protein Neighboring gene RNA-binding S4 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. Thieringer H, et al. J Cell Sci, 2003 May 1. PMID 12665560
  2. Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5. Kong J, et al. Nat Commun, 2020 Jan 29. PMID 31996685, Free PMC Article
  3. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283
  4. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome fission IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome fission ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of peroxisome size ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Peroxisomal biogenesis factor 11
NP_493273.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12971615..12972259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060872.3 → NP_493273.1  Peroxisomal biogenesis factor 11 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493273.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62103
    Conserved Domains (1) summary
    pfam05648
    Location:14 → 214
    PEX11; Peroxisomal biogenesis factor 11 (PEX11)
Nucleotide Protein
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