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Opn5 opsin 5 [ Mus musculus (house mouse) ]

Gene ID: 353344, updated on 21-Apr-2024

Summary

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Official Symbol
Opn5provided by MGI
Official Full Name
opsin 5provided by MGI
Primary source
MGI:MGI:2662912
See related
Ensembl:ENSMUSG00000043972 AllianceGenome:MGI:2662912
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGR12; Gpr136; TMEM13; Neuropsin
Summary
Enables 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Involved in entrainment of circadian clock by photoperiod; hyaloid vascular plexus regression; and phototransduction, UV. Predicted to be located in cytoplasm and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human OPN5 (opsin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
17 19.65 cM; 17 B3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (42867670..42922321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (42556779..42611430, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42558 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_42559 Neighboring gene STARR-seq mESC enhancer starr_42560 Neighboring gene STARR-seq mESC enhancer starr_42561 Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene STARR-seq mESC enhancer starr_42562 Neighboring gene STARR-seq mESC enhancer starr_42563 Neighboring gene STARR-seq mESC enhancer starr_42564 Neighboring gene STARR-seq mESC enhancer starr_42565 Neighboring gene STARR-seq mESC enhancer starr_42566 Neighboring gene patched domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_42567 Neighboring gene STARR-seq mESC enhancer starr_42568 Neighboring gene STARR-seq mESC enhancer starr_42569 Neighboring gene STARR-seq mESC enhancer starr_42570 Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene 40S ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells. Kamalabadi-Farahani M, et al. BMC Res Notes, 2022 Sep 5. PMID 36064446, Free PMC Article
  2. Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells. D'Souza SP, et al. J Comp Neurol, 2022 Jun. PMID 34743323, Free PMC Article
  3. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice. Jiang X, et al. Proc Natl Acad Sci U S A, 2021 Jun 1. PMID 34031241, Free PMC Article
  4. Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea. Díaz NM, et al. Invest Ophthalmol Vis Sci, 2020 Jun 3. PMID 32543667, Free PMC Article
  5. Neuropsin in mental health. Bukowski L, et al. J Physiol Sci, 2020 May 15. PMID 32414324, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM.
    Title: Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM.
  2. Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina.
    Title: Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina.
  3. Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells.
    Title: Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells.
  4. Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.
    Title: Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.
  5. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
    Title: Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
  6. Neuropsin in mental health.
    Title: Neuropsin in mental health.
  7. Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
    Title: Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
  8. Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
    Title: Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
  9. The study identify violet light as a developmental timing cue that, via an OPN5-dopamine pathway, regulates optic axis clearance in preparation for visual function.
    Title: An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.
  10. These results suggest that the neuropsin-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin-expressing interneurons, and that neuropsin regulates E/I balance and gamma oscillations through NRG1-ErbB4 signaling toward parvalbumin-expressing interneurons.
    Title: Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-cis retinal binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 11-cis retinal binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 11-cis retinal binding ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled photoreceptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hyaloid vascular plexus regression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phototransduction, UV ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
opsin-5
Names
G protein-coupled receptor 136
G-protein coupled receptor PGR12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181753.4 → NP_861418.2  opsin-5

    See identical proteins and their annotated locations for NP_861418.2

    Status: PROVISIONAL

    Source sequence(s)
    AC110552
    Consensus CDS
    CCDS37619.1
    UniProtKB/Swiss-Prot
    Q059L5, Q6VZZ7, Q7TQP1, Q80T51, Q8BYI2
    Related
    ENSMUSP00000063542.7, ENSMUST00000068355.8
    Conserved Domains (1) summary
    pfam00001
    Location:50 → 306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    42867670..42922321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524453.1 → XP_006524516.1  opsin-5 isoform X1

    Conserved Domains (1) summary
    cd15074
    Location:7 → 278
    7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_017317518.1 → XP_017173007.1  opsin-5 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:35 → 61
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:34 → 140
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6VZZ7.1 GenPept UniProtKB/Swiss-Prot:Q6VZZ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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