Defb37 defensin beta 37 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Defb37provided by MGI
Official Full Name: defensin beta 37provided by MGI
Primary source: MGI:MGI:2672966
See related: Ensembl:ENSMUSG00000053695 AllianceGenome:MGI:2672966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BD-37
Summary: Predicted to enable CCR6 chemokine receptor binding activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 37.1) See more
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Genomic context

Location:: 8 A1.3; 8 10.35 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (19036266..19041072, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (18986233..18991055, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490545

NoName (e-PCR)
- UniSTS:494400

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR6 chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR6 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling using intracellular calcium source	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility involved in capacitation	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvesicle	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-defensin 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.