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ZNF445 zinc finger protein 445 [ Homo sapiens (human) ]

Gene ID: 353274, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF445provided by HGNC
Official Full Name
zinc finger protein 445provided by HGNC
Primary source
HGNC:HGNC:21018
See related
Ensembl:ENSG00000185219 MIM:619508; AllianceGenome:HGNC:21018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP445; ZNF168; ZSCAN47; ZKSCAN15
Summary
Enables double-stranded methylated DNA binding activity. Involved in maintenance of DNA methylation and regulation of genetic imprinting. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3p21.31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44431705..44477670, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44447545..44493482, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44473197..44519162, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44379271-44379924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14262 Neighboring gene T cell activation inhibitor, mitochondrial Neighboring gene MPRA-validated peak4626 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44420112-44420270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19763 Neighboring gene long intergenic non-protein coding RNA 694 Neighboring gene long intergenic non-protein coding RNA 1988 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:44482886-44483092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14264 Neighboring gene uncharacterized LOC101928529 Neighboring gene zinc finger protein 852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44551492-44552268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. Luo K, et al. Gene, 2006 Feb 15. PMID 16368201
  2. Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes. Calabrò V, et al. Hum Genet, 1995 Jan. PMID 7814019
  3. ZNF445 is a primary regulator of genomic imprinting. Takahashi N, et al. Genes Dev, 2019 Jan 1. PMID 30602440, Free PMC Article
  4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126535

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epigenetic programing of female pronucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression via chromosomal CpG island methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 445
Names
zinc finger protein 168
zinc finger protein with KRAB and SCAN domains 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369454.1 → NP_001356383.1  zinc finger protein 445 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134943, AY295873
    UniProtKB/TrEMBL
    B7ZKX2
    Conserved Domains (4) summary
    smart00431
    Location:51 → 155
    SCAN; leucine rich region
    smart00349
    Location:222 → 280
    KRAB; krueppel associated box
    COG5048
    Location:583 → 1019
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:475 → 495
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_181489.6 → NP_852466.1  zinc finger protein 445 isoform 1

    See identical proteins and their annotated locations for NP_852466.1

    Status: VALIDATED

    Source sequence(s)
    AC134943, AY295873, BX108541
    Consensus CDS
    CCDS2713.1
    UniProtKB/Swiss-Prot
    P59923, Q3MJD1
    Related
    ENSP00000379387.2, ENST00000396077.8
    Conserved Domains (4) summary
    smart00431
    Location:51 → 155
    SCAN; leucine rich region
    smart00349
    Location:234 → 292
    KRAB; krueppel associated box
    COG5048
    Location:595 → 1031
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:487 → 507
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44431705..44477670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44447545..44493482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59923.1 GenPept UniProtKB/Swiss-Prot:P59923

Gene LinkOut

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