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Adam32 a disintegrin and metallopeptidase domain 32 [ Mus musculus (house mouse) ]

Gene ID: 353188, updated on 11-Apr-2024

Summary

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Official Symbol
Adam32provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 32provided by MGI
Primary source
MGI:MGI:2653822
See related
Ensembl:ENSMUSG00000037437 AllianceGenome:MGI:2653822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene was found to be expressed predominantly in the pachytene spermatocytes, where the processed protein is localized to the sperm surface. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Expression
Restricted expression toward testis adult (RPKM 110.6) See more
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Genomic context

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Location:
8 A2; 8 13.65 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25326159..25438933, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24836143..24948918, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51566 Neighboring gene predicted gene, 26208 Neighboring gene ADAM metallopeptidase domain 3 Neighboring gene STARR-seq mESC enhancer starr_20948 Neighboring gene a disintegrin and metallopeptidase domain 5 Neighboring gene STARR-seq mESC enhancer starr_20951 Neighboring gene STARR-seq mESC enhancer starr_20952 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene STARR-positive B cell enhancer mm9_chr8:26127373-26127674 Neighboring gene TM2 domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normal fertility in male mice lacking ADAM32 with testis-specific expression. Lee S, et al. Reprod Biol, 2020 Dec. PMID 32972883
  2. Identification and characterization of ADAM32 with testis-predominant gene expression. Choi I, et al. Gene, 2003 Jan 30. PMID 12568724
  3. Expression and relationship of male reproductive ADAMs in mouse. Kim T, et al. Biol Reprod, 2006 Apr. PMID 16407499
  4. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
  5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Normal fertility in male mice lacking ADAM32 with testis-specific expression.
    Title: Normal fertility in male mice lacking ADAM32 with testis-specific expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 32
Names
a disintegrin and metalloprotease domain 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293693.2 → NP_001280622.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001280622.1

    Status: VALIDATED

    Source sequence(s)
    AC117643, AC156553
    Consensus CDS
    CCDS80867.1
    UniProtKB/Swiss-Prot
    Q8K410
    Related
    ENSMUSP00000113076.2, ENSMUST00000119720.8
    Conserved Domains (5) summary
    smart00608
    Location:483 → 622
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:188 → 382
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:400 → 479
    Disintegrin; Disintegrin
    pfam01421
    Location:188 → 384
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40 → 144
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_001426375.1 → NP_001413304.1  disintegrin and metalloproteinase domain-containing protein 32 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC117643, AC156553

  3. NM_153397.3 → NP_700446.2  disintegrin and metalloproteinase domain-containing protein 32 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_700446.2

    Status: VALIDATED

    Source sequence(s)
    AC117643, AC156553
    Consensus CDS
    CCDS40300.2
    UniProtKB/Swiss-Prot
    Q6P901, Q8BJ80, Q8K410
    Related
    ENSMUSP00000113627.3, ENSMUST00000121438.9
    Conserved Domains (5) summary
    smart00608
    Location:483 → 622
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:188 → 382
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:400 → 479
    Disintegrin; Disintegrin
    pfam01421
    Location:188 → 384
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:40 → 144
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    25326159..25438933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509162.3 → XP_006509225.1  disintegrin and metalloproteinase domain-containing protein 32 isoform X1

    Conserved Domains (4) summary
    smart00608
    Location:483 → 622
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:400 → 478
    Disintegrin
    pfam01421
    Location:188 → 384
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:33 → 145
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_378789.2 RNA Sequence

  2. XR_378788.2 RNA Sequence

  3. XR_004934847.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K410.3 GenPept UniProtKB/Swiss-Prot:Q8K410

Gene LinkOut

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