Egfl7 EGF-like domain 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Egfl7provided by MGI
Official Full Name: EGF-like domain 7provided by MGI
Primary source: MGI:MGI:2449923
See related: Ensembl:ENSMUSG00000026921 AllianceGenome:MGI:2449923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zneu1; VE-statin
Summary: Enables Notch binding activity. Acts upstream of or within negative regulation of cell migration and vasculogenesis. Located in extracellular space. Is expressed in several structures, including cardiovascular system; gonad; hemolymphoid system gland; retina layer; and yolk sac. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 371.9), subcutaneous fat pad adult (RPKM 89.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 18.95 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26471095..26482694)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26581083..26592682)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocellular carcinoma cells remodel the pro-metastatic tumour microenvironment through recruitment and activation of fibroblasts via paracrine Egfl7 signaling.
Title: Hepatocellular carcinoma cells remodel the pro-metastatic tumour microenvironment through recruitment and activation of fibroblasts via paracrine Egfl7 signaling.
EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory.
Title: EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory.
EGFL7 affects the migration of epidermal stem cells in refractory diabetic wounds by regulating Notch signaling pathway.
Title: EGFL7 affects the migration of epidermal stem cells in refractory diabetic wounds by regulating Notch signaling pathway.
EGF repeats of epidermal growth factorlike domain 7 promote endothelial cell activation and tumor escape from the immune system.
Title: EGF repeats of epidermal growth factor‑like domain 7 promote endothelial cell activation and tumor escape from the immune system.
Loss of EGFL7 causes an accumulation of activated neural stem cells, which display enhanced activity and re-entry into the cell cycle.
Title: Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.
EGFL7 reduces CNS inflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
Title: EGFL7 reduces CNS inflammation in mouse.
Egfl7 is crucial for placental vascularization and embryonic growth.
Title: Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function.
the angiogenic factor Egfl7 activates the Flt3/Flt3 ligand pathway and is a key molecular driver enforcing thymus progenitor generation and thereby directly links endothelial cell biology to the production of T cell-based adaptive immunity
Title: The angiogenic factor Egfl7 alters thymogenesis by activating Flt3 signaling.
EGFL7 is required for VEGF upregulation of the Akt/Erk (1/2) pathway during angiogenesis.
Title: EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay.
EGFL7 enhances EGFR-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells.
Title: Epidermal growth factor-like domain-containing protein 7 (EGFL7) enhances EGF receptor-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Egfl7 (e-PCR), detects polymorphism
- UniSTS:547849

Egfl7 (e-PCR), detects polymorphism
- UniSTS:470959

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in blood vessel development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	TAS Traceable Author Statement more info	PubMed
acts_upstream_of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in vasculogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: epidermal growth factor-like protein 7

Names: EGF-like protein 7; NEU1 protein; NOTCH4-like protein; multiple EGF-like domains protein 7; multiple epidermal growth factor-like domains protein 7; vascular endothelial statin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164564.2 → NP_001158036.2 epidermal growth factor-like protein 7 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL732311, BX649422

Consensus CDS

CCDS15807.3

UniProtKB/Swiss-Prot

Q6XD35, Q9DCP5, Q9QXT5

UniProtKB/TrEMBL

Q3UTJ7

Related

ENSMUSP00000159032.2, ENSMUST00000239075.2

Conserved Domains (4) summary

PRK00591
Location:197 → 222

prfA; peptide chain release factor 1; Validated

cd00054
Location:111 → 136

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07546
Location:42 → 94

EMI; EMI domain

pfam07645
Location:138 → 177

EGF_CA; Calcium-binding EGF domain
NM_178444.5 → NP_848538.4 epidermal growth factor-like protein 7 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL732311, BX649422

Consensus CDS

CCDS15807.3

UniProtKB/Swiss-Prot

Q6XD35, Q9DCP5, Q9QXT5

UniProtKB/TrEMBL

Q3UTJ7

Related

ENSMUSP00000128741.4, ENSMUST00000166920.10

Conserved Domains (4) summary

PRK00591
Location:197 → 222

prfA; peptide chain release factor 1; Validated

cd00054
Location:111 → 136

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07546
Location:42 → 94

EMI; EMI domain

pfam07645
Location:138 → 177

EGF_CA; Calcium-binding EGF domain
NM_198724.3 → NP_942017.3 epidermal growth factor-like protein 7 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL732311, BX649422

Consensus CDS

CCDS15807.3

UniProtKB/Swiss-Prot

Q6XD35, Q9DCP5, Q9QXT5

UniProtKB/TrEMBL

Q3UTJ7

Related

ENSMUSP00000099971.7, ENSMUST00000102907.13

Conserved Domains (4) summary

PRK00591
Location:197 → 222

prfA; peptide chain release factor 1; Validated

cd00054
Location:111 → 136

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07546
Location:42 → 94

EMI; EMI domain

pfam07645
Location:138 → 177

EGF_CA; Calcium-binding EGF domain
NM_198725.3 → NP_942018.3 epidermal growth factor-like protein 7 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL732311, BX649422

Consensus CDS

CCDS15808.3

UniProtKB/TrEMBL

Q3UTJ7

Related

ENSMUSP00000097863.7, ENSMUST00000100290.13

Conserved Domains (4) summary

PRK00591
Location:197 → 222

prfA; peptide chain release factor 1; Validated

cd00054
Location:111 → 136

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07546
Location:42 → 94

EMI; EMI domain

pfam07645
Location:138 → 177

EGF_CA; Calcium-binding EGF domain