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Prss33 serine protease 33 [ Mus musculus (house mouse) ]

Gene ID: 353130, updated on 21-Apr-2024

Summary

Official Symbol
Prss33provided by MGI
Official Full Name
serine protease 33provided by MGI
Primary source
MGI:MGI:2661234
See related
Ensembl:ENSMUSG00000049620 AllianceGenome:MGI:2661234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eos; mT6; tryptase-6
Summary
Enables serine-type peptidase activity. Predicted to be involved in protein kinase C signaling and proteolysis. Located in extracellular space. Is expressed in several structures, including brain; musculature; reproductive system; sensory organ; and spleen. Orthologous to human PRSS33 (serine protease 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
17 A3.3; 17 12.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24052312..24055667, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23833338..23836693, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene microRNA 5125 Neighboring gene STARR-positive B cell enhancer ABC_E11792 Neighboring gene elongin B Neighboring gene serine protease 41 Neighboring gene serine protease 32

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Clone Names

  • MGC123869, MGC123870, MGC123871

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IC
Inferred by Curator
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine protease 33
Names
protease, serine 33
serine protease EOS
tryptase 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081399.2NP_001074868.2  serine protease 33 precursor

    See identical proteins and their annotated locations for NP_001074868.2

    Status: VALIDATED

    Source sequence(s)
    AC122821, BC103542, BQ893522
    Consensus CDS
    CCDS37476.2
    UniProtKB/Swiss-Prot
    Q3ZB43, Q80WM7
    Related
    ENSMUSP00000059491.7, ENSMUST00000059906.8
    Conserved Domains (2) summary
    smart00020
    Location:33271
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:34272
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24052312..24055667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317516.1XP_017173005.1  serine protease 33 isoform X1

    Conserved Domains (1) summary
    cd00190
    Location:98336
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006524451.3XP_006524514.1  serine protease 33 isoform X2

    See identical proteins and their annotated locations for XP_006524514.1

    UniProtKB/Swiss-Prot
    Q80WM7
    Conserved Domains (1) summary
    cd00190
    Location:16254
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178370.2: Suppressed sequence

    Description
    NM_178370.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.