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GPR142 G protein-coupled receptor 142 [ Homo sapiens (human) ]

Gene ID: 350383, updated on 5-Mar-2024

Summary

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Official Symbol
GPR142provided by HGNC
Official Full Name
G protein-coupled receptor 142provided by HGNC
Primary source
HGNC:HGNC:20088
See related
Ensembl:ENSG00000257008 MIM:609046; AllianceGenome:HGNC:20088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR2; GPRg1b
Summary
GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in stomach (RPKM 1.1), spleen (RPKM 0.3) and 9 other tissues See more
Orthologs
mouse all
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Genomic context

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See GPR142 in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74367506..74372600)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75258167..75263271)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72363645..72368739)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 19 Neighboring gene uncharacterized LOC107985078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72348389-72348919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72353094-72353966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8930 Neighboring gene BTB domain containing 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72364259-72365247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8931 Neighboring gene uncharacterized LOC124904055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72382905-72383799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390282-72390782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390783-72391283 Neighboring gene Sharpr-MPRA regulatory region 691 Neighboring gene RNA, 5S ribosomal pseudogene 448

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Discovery and pharmacological effects of a novel GPR142 antagonist. Murakoshi M, et al. J Recept Signal Transduct Res, 2017 Jun. PMID 27807998
  2. Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system. Matsuo A, et al. Biochem Biophys Res Commun, 2005 May 27. PMID 15845401
  3. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
  4. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. Guo Z, et al. J Proteome Res, 2012 Oct 5. PMID 22889411
  5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 142
Names
G-protein coupled receptor 142 long form
G-protein coupled receptor PGR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331076.1 → NP_001318005.1  probable G-protein coupled receptor 142 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AY288421, BC143807
    Consensus CDS
    CCDS92387.1
    UniProtKB/TrEMBL
    A0A1C9J7K7, J3QSD0
    Related
    ENSP00000464632.2, ENST00000582579.6

  2. NM_001331077.1 → NP_001318006.1  probable G-protein coupled receptor 142 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AY288421, DY312809, DY312859
    Consensus CDS
    CCDS92387.1
    UniProtKB/TrEMBL
    A0A1C9J7K7, J3QSD0

  3. NM_181790.1 → NP_861455.1  probable G-protein coupled receptor 142 isoform a

    See identical proteins and their annotated locations for NP_861455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AY288421
    Consensus CDS
    CCDS11698.1
    UniProtKB/Swiss-Prot
    A4CYJ8, Q7Z601, Q86SL3
    Related
    ENSP00000335158.4, ENST00000335666.4
    Conserved Domains (1) summary
    pfam00001
    Location:176 → 414
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74367506..74372600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75258167..75263271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z601.1 GenPept UniProtKB/Swiss-Prot:Q7Z601

Gene LinkOut

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