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MCRIP1 MAPK regulated corepressor interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 348262, updated on 10-Dec-2024

Summary

Official Symbol
MCRIP1provided by HGNC
Official Full Name
MAPK regulated corepressor interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:28007
See related
Ensembl:ENSG00000225663 MIM:616514; AllianceGenome:HGNC:28007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAN2; MCRIP; FAM195B
Summary
Involved in regulation of epithelial to mesenchymal transition. Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis (RPKM 31.8), fat (RPKM 25.2) and 25 other tissues See more
Orthologs
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Genomic context

See MCRIP1 in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81822361..81833291, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82689526..82700456, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79780237..79791167, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79699122-79699658 Neighboring gene uncharacterized LOC105376789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79761495-79761994 Neighboring gene glucagon receptor Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79781934-79782157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79783828-79784461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789117-79789630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789631-79790144 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79791171-79791684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792198-79792710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792711-79793223 Neighboring gene protein phosphatase 1 regulatory subunit 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79813353-79813852 Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9154

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

General gene information

Clone Names

  • MGC133184, DKFZp686A17165

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytoplasmic stress granule PubMed 
located_in nucleus PubMed 

General protein information

Preferred Names
mapk-regulated corepressor-interacting protein 1
Names
MAPK-regulated co-repressor interacting protein 1
family with sequence similarity 195, member B
granulin-2
protein FAM195B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093767.3NP_001087236.1  mapk-regulated corepressor-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001087236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BE831904, BX649156
    Consensus CDS
    CCDS45814.1
    UniProtKB/Swiss-Prot
    C9JLW8, Q6ZUL0
    UniProtKB/TrEMBL
    I3L2L5
    Related
    ENSP00000445543.1, ENST00000538396.5
    Conserved Domains (1) summary
    pfam14799
    Location:489
    FAM195; FAM195 family
  2. NM_001288798.2NP_001275727.1  mapk-regulated corepressor-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001275727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (1).
    Source sequence(s)
    BC094876, BE831904, BG830426
    Consensus CDS
    CCDS74179.1
    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0
    Related
    ENSP00000461433.1, ENST00000572645.5
    Conserved Domains (1) summary
    pfam14799
    Location:25110
    FAM195; FAM195 family
  3. NM_001288799.2NP_001275728.1  mapk-regulated corepressor-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001275728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, resulting in different UTRs and translation initiation at a downstream start codon, compared to variant 3. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    BC063557, BE831904, BG830426, BU188846
    Consensus CDS
    CCDS74178.1
    UniProtKB/TrEMBL
    I3L3A7
    Related
    ENSP00000460299.1, ENST00000573478.5
    Conserved Domains (1) summary
    pfam14799
    Location:443
    FAM195; FAM195 family
  4. NM_207368.5NP_997251.2  mapk-regulated corepressor-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_997251.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the UTRs, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK000852, BC094876, BE831904, BG830426
    Consensus CDS
    CCDS45814.1
    UniProtKB/Swiss-Prot
    C9JLW8, Q6ZUL0
    UniProtKB/TrEMBL
    I3L2L5
    Related
    ENSP00000409009.2, ENST00000455127.7
    Conserved Domains (1) summary
    pfam14799
    Location:489
    FAM195; FAM195 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81822361..81833291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435914.1XP_047291870.1  mapk-regulated corepressor-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    I3L3A7
  2. XM_047435913.1XP_047291869.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  3. XM_011523572.3XP_011521874.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011521874.1

    Conserved Domains (1) summary
    pfam14799
    Location:2576
    FAM195; FAM195 family
  4. XM_011523571.3XP_011521873.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521873.1

    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0
    Related
    ENSP00000460461.1, ENST00000575061.2
    Conserved Domains (1) summary
    pfam14799
    Location:25110
    FAM195; FAM195 family

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160021.1 Reference GRCh38.p14 PATCHES

    Range
    35854..46784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332669.1XP_054188644.1  mapk-regulated corepressor-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    I3L3A7
  2. XM_054332668.1XP_054188643.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  3. XM_054332667.1XP_054188642.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  4. XM_054332666.1XP_054188641.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82689526..82700456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315951.1XP_054171926.1  mapk-regulated corepressor-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    I3L3A7
  2. XM_054315950.1XP_054171925.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  3. XM_054315949.1XP_054171924.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  4. XM_054315948.1XP_054171923.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0
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