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MCRIP1 MAPK regulated corepressor interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 348262, updated on 5-Mar-2024

Summary

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Official Symbol
MCRIP1provided by HGNC
Official Full Name
MAPK regulated corepressor interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:28007
See related
Ensembl:ENSG00000225663 MIM:616514; AllianceGenome:HGNC:28007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAN2; MCRIP; FAM195B
Summary
Involved in regulation of epithelial to mesenchymal transition. Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 31.8), fat (RPKM 25.2) and 25 other tissues See more
Orthologs
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Genomic context

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See MCRIP1 in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81822361..81833291, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82689526..82700456, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79780237..79791167, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79699122-79699658 Neighboring gene uncharacterized LOC105376789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79761495-79761994 Neighboring gene glucagon receptor Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79781934-79782157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79783828-79784461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789117-79789630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789631-79790144 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79791171-79791684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792198-79792710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792711-79793223 Neighboring gene protein phosphatase 1 regulatory subunit 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79813353-79813852 Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9154

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. Ichikawa K, et al. Mol Cell, 2015 Apr 2. PMID 25728771
  2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Bish R, et al. Biomolecules, 2015 Jul 15. PMID 26184334, Free PMC Article
  3. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. MacLeod G, et al. Cell Rep, 2019 Apr 16. PMID 30995489
  4. KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II. McNamara RP, et al. Mol Cell, 2016 Jan 7. PMID 26725010, Free PMC Article
  5. Physiological and pathophysiological characteristics of ataxin-3 isoforms. Weishäupl D, et al. J Biol Chem, 2019 Jan 11. PMID 30455355, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.
    Title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133184, DKFZp686A17165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mapk-regulated corepressor-interacting protein 1
Names
MAPK-regulated co-repressor interacting protein 1
family with sequence similarity 195, member B
granulin-2
protein FAM195B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093767.3 → NP_001087236.1  mapk-regulated corepressor-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001087236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    BE831904, BX649156
    Consensus CDS
    CCDS45814.1
    UniProtKB/Swiss-Prot
    C9JLW8, Q6ZUL0
    UniProtKB/TrEMBL
    I3L2L5
    Related
    ENSP00000445543.1, ENST00000538396.5
    Conserved Domains (1) summary
    pfam14799
    Location:4 → 89
    FAM195; FAM195 family

  2. NM_001288798.2 → NP_001275727.1  mapk-regulated corepressor-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001275727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (1).
    Source sequence(s)
    BC094876, BE831904, BG830426
    Consensus CDS
    CCDS74179.1
    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0
    Related
    ENSP00000461433.1, ENST00000572645.5
    Conserved Domains (1) summary
    pfam14799
    Location:25 → 110
    FAM195; FAM195 family

  3. NM_001288799.2 → NP_001275728.1  mapk-regulated corepressor-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001275728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, resulting in different UTRs and translation initiation at a downstream start codon, compared to variant 3. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    BC063557, BE831904, BG830426, BU188846
    Consensus CDS
    CCDS74178.1
    UniProtKB/TrEMBL
    I3L3A7
    Related
    ENSP00000460299.1, ENST00000573478.5
    Conserved Domains (1) summary
    pfam14799
    Location:4 → 43
    FAM195; FAM195 family

  4. NM_207368.5 → NP_997251.2  mapk-regulated corepressor-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_997251.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the UTRs, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK000852, BC094876, BE831904, BG830426
    Consensus CDS
    CCDS45814.1
    UniProtKB/Swiss-Prot
    C9JLW8, Q6ZUL0
    UniProtKB/TrEMBL
    I3L2L5
    Related
    ENSP00000409009.2, ENST00000455127.7
    Conserved Domains (1) summary
    pfam14799
    Location:4 → 89
    FAM195; FAM195 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81822361..81833291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435914.1 → XP_047291870.1  mapk-regulated corepressor-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    I3L3A7

  2. XM_047435913.1 → XP_047291869.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  3. XM_011523572.3 → XP_011521874.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011521874.1

    Conserved Domains (1) summary
    pfam14799
    Location:25 → 76
    FAM195; FAM195 family

  4. XM_011523571.3 → XP_011521873.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011521873.1

    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0
    Related
    ENSP00000460461.1, ENST00000575061.2
    Conserved Domains (1) summary
    pfam14799
    Location:25 → 110
    FAM195; FAM195 family

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160021.1 Reference GRCh38.p14 PATCHES

    Range
    35854..46784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332669.1 → XP_054188644.1  mapk-regulated corepressor-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    I3L3A7

  2. XM_054332668.1 → XP_054188643.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  3. XM_054332667.1 → XP_054188642.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  4. XM_054332666.1 → XP_054188641.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82689526..82700456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315951.1 → XP_054171926.1  mapk-regulated corepressor-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    I3L3A7

  2. XM_054315950.1 → XP_054171925.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  3. XM_054315949.1 → XP_054171924.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  4. XM_054315948.1 → XP_054171923.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A024R8W3, I3L4Q0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C9JLW8.1 GenPept UniProtKB/Swiss-Prot:C9JLW8

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