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Norad non-coding RNA activated by DNA damage [ Mus musculus (house mouse) ]

Gene ID: 347740, updated on 27-Feb-2024

Summary

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Official Symbol
Noradprovided by MGI
Official Full Name
non-coding RNA activated by DNA damageprovided by MGI
Primary source
MGI:MGI:1914767
See related
Ensembl:ENSMUSG00000102869 AllianceGenome:MGI:1914767
Gene type
ncRNA
RefSeq status
PREDICTED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810005K14Rik; 2900097C17Rik; 4930563C06Rik
Summary
Is expressed in embryo. Orthologous to human NORAD (non-coding RNA activated by DNA damage). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
2 H1; 2 77.39 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156229983..156234899, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156388063..156392979, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_06163 Neighboring gene STARR-positive B cell enhancer mm9_chr2:156182424-156182725 Neighboring gene programmed cell death 10 pseudogene Neighboring gene predicted gene 14170 Neighboring gene ribosomal protein L21, pseudogene 9 Neighboring gene ribosomal protein L37a pseudogene Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene STARR-seq mESC enhancer starr_06170 Neighboring gene STARR-seq mESC enhancer starr_06171 Neighboring gene predicted gene, 33977

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PUMILIO hyperactivity drives premature aging of Norad-deficient mice. Kopp F, et al. Elife, 2019 Feb 8. PMID 30735131, Free PMC Article
  2. LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis. Li C, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Apr 25. PMID 35607965, Free PMC Article
  3. WTAP-mediated m(6)A modification of lncRNA NORAD promotes intervertebral disc degeneration. Li G, et al. Nat Commun, 2022 Mar 18. PMID 35304463, Free PMC Article
  4. Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Krüppel-like factor 5. Fu DN, et al. Exp Cell Res, 2021 Apr 15. PMID 33636159
  5. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis.
    Title: LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis.
  2. Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Kruppel-like factor 5.
    Title: Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Krüppel-like factor 5.
  3. Norad is the preferred RNA target of PUMILIO2 (PUM2) in mouse tissues and, upon loss of Norad, PUM2 hyperactively represses key genes required for mitosis and mitochondrial function. Accordingly, enforced Pum2 expression fully phenocopies Norad deletion, resulting in rapid-onset aging-associated phenotypes.
    Title: PUMILIO hyperactivity drives premature aging of Norad-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

General gene information

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Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hair follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024329.1 RNA Sequence

    Status: PREDICTED

    Source sequence(s)
    AK077867, AL928935, BM898641
    Related
    ENSMUST00000192863.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156229983..156234899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases