U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [ Mus musculus (house mouse) ]

Gene ID: 347722, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Agap1provided by MGI
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by MGI
Primary source
MGI:MGI:2653690
See related
Ensembl:ENSMUSG00000055013 AllianceGenome:MGI:2653690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ggap1; Centg2; mKIAA1099
Summary
Predicted to enable GTPase activity and phospholipid binding activity. Predicted to act upstream of or within protein transport. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in central nervous system; peripheral nervous system ganglion; sensory organ; tooth; and vibrissa. Orthologous to several human genes including AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.5), cerebellum adult (RPKM 12.8) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 D; 1 45.06 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (89382533..89823004)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (89454811..89895282)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA C030007H22 gene Neighboring gene predicted gene, 41913 Neighboring gene STARR-seq mESC enhancer starr_01663 Neighboring gene STARR-seq mESC enhancer starr_01664 Neighboring gene predicted gene, 41914 Neighboring gene RIKEN cDNA 4933400F21 gene Neighboring gene STARR-seq mESC enhancer starr_01667 Neighboring gene STARR-seq mESC enhancer starr_01669 Neighboring gene STARR-seq mESC enhancer starr_01670 Neighboring gene uncharacterized LOC102637806 Neighboring gene STARR-seq mESC enhancer starr_01674 Neighboring gene gastrulation brain homeobox 2 Neighboring gene predicted gene, 41915 Neighboring gene ankyrin repeat and SOCS box-containing 18

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. Bendor J, et al. EMBO J, 2010 Aug 18. PMID 20664521, Free PMC Article
  2. GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Xia C, et al. Mol Cell Biol, 2003 Apr. PMID 12640130, Free PMC Article
  3. The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin. Arnold M, et al. Front Cell Neurosci, 2016. PMID 27713690, Free PMC Article
  4. AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. Meurer S, et al. J Biol Chem, 2004 Nov 19. PMID 15381706
  5. GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. Luo R, et al. J Biol Chem, 2012 May 18. PMID 22453919, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
    Title: GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
  2. The elimination of adaptor protein 3 or abrogation of AGAP1-M5 muscarinic receptor interaction in vivo decreased the magnitude of presynaptic M5 muscarinic receptor mediated dopamine release potentiation in the striatum.
    Title: AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.
  3. AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase
    Title: AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
Names
AGAP-1
centaurin-gamma-2
cnt-g2
NP_001032213.1
NP_835220.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037136.1 → NP_001032213.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC124227, AK046523, AK147503
    Consensus CDS
    CCDS15148.1
    UniProtKB/TrEMBL
    A0A087WRF2, Q3UH88
    Related
    ENSMUSP00000140599.2, ENSMUST00000190096.7
    Conserved Domains (8) summary
    cd04103
    Location:72 → 229
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00173
    Location:73 → 235
    RAS; Ras subfamily of RAS small GTPases
    cd00204
    Location:683 → 772
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:344 → 539
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:347 → 411
    PH; PH domain
    pfam01412
    Location:558 → 672
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:683 → 773
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:715 → 746
    ANK; ANK repeat [structural motif]

  2. NM_178119.3 → NP_835220.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_835220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC124227, AK046523, AK147503
    Consensus CDS
    CCDS15149.1
    UniProtKB/Swiss-Prot
    Q3UHA0, Q6ZPX9, Q8BXK8, Q8BZG0
    Related
    ENSMUSP00000027521.9, ENSMUST00000027521.15
    Conserved Domains (8) summary
    cd04103
    Location:72 → 229
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00173
    Location:73 → 235
    RAS; Ras subfamily of RAS small GTPases
    cd00204
    Location:736 → 825
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:344 → 592
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:347 → 411
    PH; PH domain
    pfam01412
    Location:611 → 725
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:736 → 826
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:768 → 799
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    89382533..89823004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXK8.1 GenPept UniProtKB/Swiss-Prot:Q8BXK8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous