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Pramel6 PRAME like 6 [ Mus musculus (house mouse) ]

Gene ID: 347711, updated on 8-Feb-2024

Summary

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Official Symbol
Pramel6provided by MGI
Official Full Name
PRAME like 6provided by MGI
Primary source
MGI:MGI:2156390
See related
Ensembl:ENSMUSG00000025838 AllianceGenome:MGI:2156390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in blastocyst; compacted morula; and inner cell mass. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
2 D; 2 49.86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (87336909..87341209)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (87506565..87510865)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 12 subfamily E member 7 Neighboring gene STARR-seq mESC enhancer starr_05041 Neighboring gene PRAME like 7 Neighboring gene STARR-seq mESC enhancer starr_05047 Neighboring gene olfactory receptor family 5 subfamily W member 9, pseudogene 1 Neighboring gene signal recognition particle 9 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3. Cinelli P, et al. BMC Dev Biol, 2008 May 23. PMID 18500982, Free PMC Article
  2. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Bortvin A, et al. Development, 2003 Apr. PMID 12620990
  3. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
  4. Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Kaji K, et al. Development, 2007 Mar. PMID 17287250
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
preferentially expressed antigen in melanoma like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356544.1 → NP_001343473.1  preferentially expressed antigen in melanoma like 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AF490342, BY031404, CN720598
    Consensus CDS
    CCDS16294.1
    UniProtKB/TrEMBL
    Q3UT28, Q810Y9

  2. NM_001356545.1 → NP_001343474.1  preferentially expressed antigen in melanoma like 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AF490342, BG079990, BY031404
    Consensus CDS
    CCDS16294.1
    UniProtKB/TrEMBL
    Q3UT28, Q810Y9

  3. NM_001356546.1 → NP_001343475.1  preferentially expressed antigen in melanoma like 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AF490342, AL928797
    Consensus CDS
    CCDS16294.1
    UniProtKB/TrEMBL
    Q3UT28, Q810Y9
    Related
    ENSMUSP00000026956.4, ENSMUST00000026956.4

  4. NM_178249.3 → NP_839980.1  preferentially expressed antigen in melanoma like 6

    See identical proteins and their annotated locations for NP_839980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AF490342, AK139830
    Consensus CDS
    CCDS16294.1
    UniProtKB/TrEMBL
    Q3UT28, Q810Y9
    Related
    ENSMUSP00000107198.2, ENSMUST00000111572.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    87336909..87341209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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