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IGFBPL1 insulin like growth factor binding protein like 1 [ Homo sapiens (human) ]

Gene ID: 347252, updated on 5-Mar-2024

Summary

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Official Symbol
IGFBPL1provided by HGNC
Official Full Name
insulin like growth factor binding protein like 1provided by HGNC
Primary source
HGNC:HGNC:20081
See related
Ensembl:ENSG00000137142 MIM:610413; AllianceGenome:HGNC:20081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGFBPRP4; IGFBP-RP4; bA113O24.1
Summary
Predicted to enable insulin-like growth factor binding activity. Involved in cellular response to tumor cell. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 9.9), brain (RPKM 1.8) and 3 other tissues See more
Orthologs
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Genomic context

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See IGFBPL1 in Genome Data Viewer
Location:
9p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (38406528..38424454, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (38430707..38448634, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (38406525..38424451, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987065 Neighboring gene uncharacterized LOC105376040 Neighboring gene Sharpr-MPRA regulatory region 3476 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:38380800-38381748 Neighboring gene Sharpr-MPRA regulatory region 2586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28416 Neighboring gene aldehyde dehydrogenase 1 family member B1 Neighboring gene uncharacterized LOC105376041 Neighboring gene VISTA enhancer hs1390 Neighboring gene Sharpr-MPRA regulatory region 10144 Neighboring gene armadillo repeat containing 8 pseudogene 1 Neighboring gene transcription elongation factor A1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Neural precursor cells tune striatal connectivity through the release of IGFBPL1. Butti E, et al. Nat Commun, 2022 Dec 8. PMID 36482070, Free PMC Article
  2. Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling. Liu Y, et al. Clin Epigenetics, 2020 Feb 10. PMID 32041673, Free PMC Article
  3. Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells. Kutsukake M, et al. Mol Hum Reprod, 2007 Oct. PMID 17884839
  4. Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes. Smith P, et al. Clin Cancer Res, 2007 Jul 15. PMID 17634530
  5. Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties. Cai Z, et al. Biochem Biophys Res Commun, 2005 May 27. PMID 15845387

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IGFBPL1 inhibits macrophage lipid accumulation by enhancing the activation of IGR1R/LXRalpha/ABCG1 pathway.
    Title: IGFBPL1 inhibits macrophage lipid accumulation by enhancing the activation of IGR1R/LXRα/ABCG1 pathway.
  2. IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy.
    Title: IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy.
  3. Neural precursor cells tune striatal connectivity through the release of IGFBPL1.
    Title: Neural precursor cells tune striatal connectivity through the release of IGFBPL1.
  4. Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
    Title: Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
  5. Expression of IGFBPL1 correlates with RGC axon growth, and acute knockdown of IGFBPL1 with shRNA or IGFBPL1 knockout in vivo impaired RGC axon growth. IGFBPL1 binds IGF-1, induces calcium signaling mTOR phosphorylation.
    Title: IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades.
  6. These results suggest that insulin-like growth factor-binding protein-related protein 1 may play a role in decidualization of human endometrial stromal cells.
    Title: Involvement of insulin-like growth factor-binding protein-related protein 1 in decidualization of human endometrial stromal cells.
  7. Expression of IGFBPL1 is regulated by aberrant hypermethylation in breast cancer, implying that inactivation of these genes is involved in the pathogenesis of this malignancy.
    Title: Epigenetic inactivation implies independent functions for insulin-like growth factor binding protein (IGFBP)-related protein 1 and the related IGFBPL1 in inhibiting breast cancer phenotypes.
  8. IGFBP-RP4 may be a novel putative tumor suppressor protein.
    Title: Identification of a novel insulin-like growth factor binding protein gene homologue with tumor suppressor like properties.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to tumor cell IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor-binding protein-like 1
Names
IGFBP-related protein 10
insulin-like growth factor binding protein related protein 4
insulin-like growth factor-binding-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007563.3 → NP_001007564.1  insulin-like growth factor-binding protein-like 1 precursor

    See identical proteins and their annotated locations for NP_001007564.1

    Status: VALIDATED

    Source sequence(s)
    AL135785
    Consensus CDS
    CCDS35017.1
    UniProtKB/Swiss-Prot
    Q8WX77
    Related
    ENSP00000366923.1, ENST00000377694.2
    Conserved Domains (2) summary
    smart00280
    Location:114 → 151
    KAZAL; Kazal type serine protease inhibitors
    cl28434
    Location:169 → 260
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    38406528..38424454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014699.2 → XP_016870188.1  insulin-like growth factor-binding protein-like 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    38430707..38448634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362918.1 → XP_054218893.1  insulin-like growth factor-binding protein-like 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WX77.1 GenPept UniProtKB/Swiss-Prot:Q8WX77

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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