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KIF24 kinesin family member 24 [ Homo sapiens (human) ]

Gene ID: 347240, updated on 5-Mar-2024

Summary

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Official Symbol
KIF24provided by HGNC
Official Full Name
kinesin family member 24provided by HGNC
Primary source
HGNC:HGNC:19916
See related
Ensembl:ENSG00000186638 MIM:613747; AllianceGenome:HGNC:19916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf48; bA571F15.4
Summary
This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]
Expression
Broad expression in testis (RPKM 7.5), bone marrow (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

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See KIF24 in Genome Data Viewer
Location:
9p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34252380..34333671, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34271317..34378395, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34252378..34329266, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ubiquitin associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 282 Neighboring gene MPRA-validated peak7226 silencer Neighboring gene ribosomal protein S8 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19843 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:34254397-34255596 Neighboring gene RNA, U2 small nuclear 50, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34318623-34319288 Neighboring gene serpin family H member 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:34329280-34329787 Neighboring gene nudix hydrolase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34371826-34372326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34372327-34372827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34375663-34376244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34376245-34376825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34380811-34381416 Neighboring gene uncharacterized LOC124902144 Neighboring gene myogenesis regulating glycosidase (putative) Neighboring gene sperm microtubule inner protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia. Reilly ML, et al. J Bone Miner Res, 2022 Sep. PMID 35748595, Free PMC Article
  2. Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance. Zou JX, et al. Mol Cancer Res, 2014 Apr. PMID 24391143, Free PMC Article
  3. Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle. Kim S, et al. Nat Commun, 2015 Aug 20. PMID 26290419, Free PMC Article
  4. Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? Venturelli E, et al. Neurosci Lett, 2010 Oct 4. PMID 20670673
  5. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. Kobayashi T, et al. Cell, 2011 Jun 10. PMID 21620453

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia.
    Title: Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia.
  2. Kif24 is a physiological substrate of Nek2, which regulates cilia disassembly through a concerted mechanism involving Kif24-mediated microtubule depolymerization.
    Title: Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle.
  3. Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly.
    Title: Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis.
  4. KIF24 rs17350674 polymorphism likely acts as a risk factor for sporadic Lobar Degeneration
    Title: Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration?
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration?
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10933, FLJ43884, MGC125677, MGC125678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053094.1 RefSeqGene

    Range
    8705..85593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_194313.4 → NP_919289.2  kinesin-like protein KIF24

    See identical proteins and their annotated locations for NP_919289.2

    Status: REVIEWED

    Source sequence(s)
    AK125180, AL353662, BC110502, BE856625, BF895212, BP871643, BU660279, DA906271, DT932659, DV080193, DV080194, HY066968
    Consensus CDS
    CCDS6551.2
    UniProtKB/Swiss-Prot
    Q2TB93, Q5T7B5, Q5T7B7, Q5T7B8, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
    Related
    ENSP00000384433.1, ENST00000402558.7
    Conserved Domains (3) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:223 → 544
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:229 → 545
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    34252380..34333671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517863.4 → XP_011516165.1  kinesin-like protein KIF24 isoform X2

    See identical proteins and their annotated locations for XP_011516165.1

    UniProtKB/Swiss-Prot
    Q2TB93, Q5T7B5, Q5T7B7, Q5T7B8, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
    Conserved Domains (3) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:223 → 544
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:229 → 545
    Kinesin; Kinesin motor domain

  2. XM_047423343.1 → XP_047279299.1  kinesin-like protein KIF24 isoform X5

    Related
    ENSP00000368472.3, ENST00000379174.7

  3. XM_047423340.1 → XP_047279296.1  kinesin-like protein KIF24 isoform X3

  4. XM_047423342.1 → XP_047279298.1  kinesin-like protein KIF24 isoform X4

  5. XM_011517861.3 → XP_011516163.1  kinesin-like protein KIF24 isoform X1

    See identical proteins and their annotated locations for XP_011516163.1

    Conserved Domains (3) summary
    cd09541
    Location:34 → 93
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:254 → 575
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:260 → 576
    Kinesin; Kinesin motor domain

  6. XM_017014697.3 → XP_016870186.1  kinesin-like protein KIF24 isoform X2

    UniProtKB/Swiss-Prot
    Q2TB93, Q5T7B5, Q5T7B7, Q5T7B8, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
    Conserved Domains (3) summary
    cd09541
    Location:3 → 62
    SAM_KIF24-like; SAM domain of KIF24-like subfamily
    cd01367
    Location:223 → 544
    KISc_KIF2_like; Kinesin motor domain, KIF2-like group
    pfam00225
    Location:229 → 545
    Kinesin; Kinesin motor domain

  7. XM_047423345.1 → XP_047279301.1  kinesin-like protein KIF24 isoform X7

  8. XM_047423344.1 → XP_047279300.1  kinesin-like protein KIF24 isoform X6

  9. XM_006716764.4 → XP_006716827.1  kinesin-like protein KIF24 isoform X8

    Conserved Domains (1) summary
    cl22853
    Location:47 → 86
    Motor_domain; Myosin and Kinesin motor domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    34271317..34378395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362910.1 → XP_054218885.1  kinesin-like protein KIF24 isoform X2

  2. XM_054362914.1 → XP_054218889.1  kinesin-like protein KIF24 isoform X5

  3. XM_054362912.1 → XP_054218887.1  kinesin-like protein KIF24 isoform X3

  4. XM_054362913.1 → XP_054218888.1  kinesin-like protein KIF24 isoform X4

  5. XM_054362909.1 → XP_054218884.1  kinesin-like protein KIF24 isoform X1

  6. XM_054362911.1 → XP_054218886.1  kinesin-like protein KIF24 isoform X2

  7. XM_054362916.1 → XP_054218891.1  kinesin-like protein KIF24 isoform X7

  8. XM_054362915.1 → XP_054218890.1  kinesin-like protein KIF24 isoform X6

  9. XM_054362917.1 → XP_054218892.1  kinesin-like protein KIF24 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T7B8.2 GenPept UniProtKB/Swiss-Prot:Q5T7B8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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