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STRA8 stimulated by retinoic acid 8 [ Homo sapiens (human) ]

Gene ID: 346673, updated on 3-Apr-2024

Summary

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Official Symbol
STRA8provided by HGNC
Official Full Name
stimulated by retinoic acid 8provided by HGNC
Primary source
HGNC:HGNC:30653
See related
Ensembl:ENSG00000146857 MIM:609987; AllianceGenome:HGNC:30653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See STRA8 in Genome Data Viewer
Location:
7q33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135231915..135258663)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136539792..136566564)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134916667..134943415)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene transmembrane protein 140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134893611-134894810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18678 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene uncharacterized LOC107984123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26714 Neighboring gene solute carrier family 23 member 4, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134998844-134999016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135023371-135023872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:135023873-135024372 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:135032494-135032998 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:135065068-135065648 Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene succinate dehydrogenase complex subunit D pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. Le Bouffant R, et al. Hum Reprod, 2010 Oct. PMID 20670969
  2. [Genetics and male infertility]. Stouffs K, et al. Verh K Acad Geneeskd Belg, 2009. PMID 20088251
  3. Xeno-free culture of human spermatogonial stem cells supported by human embryonic stem cell-derived fibroblast-like cells. Chen B, et al. Asian J Androl, 2009 Sep. PMID 19734913, Free PMC Article
  4. Global gene expression in the human fetal testis and ovary. Houmard B, et al. Biol Reprod, 2009 Aug. PMID 19369649, Free PMC Article
  5. Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. Anderson EL, et al. Proc Natl Acad Sci U S A, 2008 Sep 30. PMID 18799751, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ cell specific bHLH factor SOHLH1 and represses c-KIT expression in vitro.
    Title: Stimulated by retinoic acid gene 8 (STRA8) interacts with the germ cell specific bHLH factor SOHLH1 and represses c-KIT expression in vitro.
  2. The genetic variant rs10269148 of STRA8 gene shows higher risk of spermatogenic impairment in the groups of abnormospermia than the controls
    Title: Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population.
  3. Functional characterization of an homologous mouse gene.
    Title: Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
  5. Expression restricted to testis (STRA8)
    Title: Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of meiosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
stimulated by retinoic acid gene 8 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394401.1 → NP_001381330.1  stimulated by retinoic acid gene 8 protein homolog isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC009542
    Consensus CDS
    CCDS94209.1
    UniProtKB/Swiss-Prot
    Q7Z7C7
    UniProtKB/TrEMBL
    A0A590UJF1
    Related
    ENSP00000499386.1, ENST00000662584.2
    Conserved Domains (1) summary
    cl00081
    Location:31 → 90
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  2. NM_182489.3 → NP_872295.2  stimulated by retinoic acid gene 8 protein homolog isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009542
    Consensus CDS
    CCDS5839.2
    UniProtKB/Swiss-Prot
    Q7Z7C7
    UniProtKB/TrEMBL
    A0A590UK75
    Related
    ENSP00000499721.1, ENST00000667288.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    135231915..135258663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516137.3 → XP_011514439.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

    See identical proteins and their annotated locations for XP_011514439.1

    UniProtKB/Swiss-Prot
    Q7Z7C7
    UniProtKB/TrEMBL
    A0A590UJF1
    Conserved Domains (1) summary
    cl00081
    Location:31 → 90
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  2. XM_047420324.1 → XP_047276280.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A590UJF1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    136539792..136566564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358113.1 → XP_054214088.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

  2. XM_054358114.1 → XP_054214089.1  stimulated by retinoic acid gene 8 protein homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7C7.1 GenPept UniProtKB/Swiss-Prot:Q7Z7C7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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