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MOGAT3 monoacylglycerol O-acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 346606, updated on 5-Mar-2024

Summary

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Official Symbol
MOGAT3provided by HGNC
Official Full Name
monoacylglycerol O-acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:23249
See related
Ensembl:ENSG00000106384 MIM:610184; AllianceGenome:HGNC:23249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC7; MGAT3; DGAT2L2
Summary
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in small intestine (RPKM 14.2), duodenum (RPKM 14.1) and 3 other tissues See more
Orthologs
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Genomic context

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See MOGAT3 in Genome Data Viewer
Location:
7q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101192886..101201036, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102516352..102524499, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100838288..100844317, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18478 Neighboring gene VGF nerve growth factor inducible Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100812095-100812265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100814834-100815448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100815449-100816062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100816063-100816676 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100816815-100817027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100817327-100817832 Neighboring gene N-acetyltransferase 16 (putative) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100823355-100824077 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100825811-100826028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100838952-100839452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100845469-100846276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100846277-100847083 Neighboring gene diacylglycerol O-acyltransferase 2 like 7, pseudogene Neighboring gene ribosomal protein SA pseudogene 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. Cheng D, et al. J Biol Chem, 2003 Apr 18. PMID 12618427
  2. Biochemical characterization of human acyl coenzyme A: 2-monoacylglycerol acyltransferase-3 (MGAT3). Brandt C, et al. Biochem Biophys Res Commun, 2016 Jul 1. PMID 27184406
  3. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. Winter A, et al. Cytogenet Genome Res, 2003. PMID 14970677
  4. Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases. Ma Z, et al. J Lipid Res, 2017 Jun. PMID 28420705, Free PMC Article
  5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MGAT3 encodes a approximately 36-kDa transmembrane protein that is highly homologous to MGAT1 and -2 and is expressed in the human gastrointestinal tract with the highest level found in the ileum
    Title: Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119203, MGC119204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-acylglycerol O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monoacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in perinuclear endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2-acylglycerol O-acyltransferase 3
Names
acyl coenzyme A:monoacylglycerol acyltransferase 3
acyl-CoA:monoacylglycerol acyltransferase 3
diacylglycerol O-acyltransferase candidate 7
diacylglycerol acyltransferase 2-like protein 7
NP_001274076.1
NP_835470.1
XP_005250366.1
XP_054214087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287147.2 → NP_001274076.1  2-acylglycerol O-acyltransferase 3 isoform b

    See identical proteins and their annotated locations for NP_001274076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC004876, AY229854, BC100955, BE042458
    Consensus CDS
    CCDS75643.1
    UniProtKB/Swiss-Prot
    Q86VF5
    Related
    ENSP00000368734.3, ENST00000379423.3
    Conserved Domains (1) summary
    cl17185
    Location:45 → 220
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

  2. NM_178176.4 → NP_835470.1  2-acylglycerol O-acyltransferase 3 isoform a

    See identical proteins and their annotated locations for NP_835470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC004876, AY229854, BE042458
    Consensus CDS
    CCDS5714.1
    UniProtKB/Swiss-Prot
    Q496A6, Q496A7, Q496A8, Q86VF5, Q9UDW7
    Related
    ENSP00000223114.4, ENST00000223114.9
    Conserved Domains (1) summary
    cl17185
    Location:45 → 340
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    101192886..101201036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250309.4 → XP_005250366.1  2-acylglycerol O-acyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_005250366.1

    UniProtKB/Swiss-Prot
    Q86VF5
    Related
    ENSP00000403756.2, ENST00000440203.6
    Conserved Domains (1) summary
    cl17185
    Location:45 → 290
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RNA

  1. XR_001744700.2 RNA Sequence

  2. XR_001744701.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102516352..102524499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358112.1 → XP_054214087.1  2-acylglycerol O-acyltransferase 3 isoform X1

RNA

  1. XR_008487597.1 RNA Sequence

  2. XR_008487598.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86VF5.1 GenPept UniProtKB/Swiss-Prot:Q86VF5

Gene LinkOut

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