U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CD200R1L CD200 receptor 1 like [ Homo sapiens (human) ]

Gene ID: 344807, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CD200R1Lprovided by HGNC
Official Full Name
CD200 receptor 1 likeprovided by HGNC
Primary source
HGNC:HGNC:24665
See related
Ensembl:ENSG00000206531 AllianceGenome:HGNC:24665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD200R2; CD200RLa
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in regulation of neuroinflammatory response. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Low expression observed in reference dataset See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (112815711..112846864, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115536646..115567808, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112534558..112565711, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene MAT2A pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:112463594-112464448 Neighboring gene long intergenic non-protein coding RNA 2042 Neighboring gene microRNA 9900 Neighboring gene Sharpr-MPRA regulatory region 12929 Neighboring gene CD200R1L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112543386-112543886 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:112563646-112563805 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112590118-112590618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112603434-112604024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112604025-112604615 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:112612841-112614040 Neighboring gene CD200R1 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64462 Neighboring gene CD200 receptor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Minas K, et al. Crit Rev Immunol, 2006. PMID 16928187, Free PMC Article
  2. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. Voehringer D, et al. J Biol Chem, 2004 Dec 24. PMID 15471863
  3. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. Wright GJ, et al. J Immunol, 2003 Sep 15. PMID 12960329
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. Tao S, et al. Carcinogenesis, 2012 Mar. PMID 22219177, Free PMC Article
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cell surface glycoprotein CD200 receptor 2
Names
CD200 cell surface glycoprotein receptor 2
CD200 cell surface glycoprotein receptor-like 2
CD200 cell surface glycoprotein receptor-like a
CD200 receptor 2
CD200 receptor-like 2
cell surface glycoprotein CD200 receptor 1-like
cell surface glycoprotein OX2 receptor 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008784.4 → NP_001008784.2  cell surface glycoprotein CD200 receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008784.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (1).
    Source sequence(s)
    AC074044, AC092892
    Consensus CDS
    CCDS43131.1
    UniProtKB/Swiss-Prot
    Q6Q8B3, Q6WHB7
    Related
    ENSP00000381272.1, ENST00000398214.5
    Conserved Domains (1) summary
    cl11960
    Location:156 → 224
    Ig; Immunoglobulin domain

  2. NM_001199215.3 → NP_001186144.1  cell surface glycoprotein CD200 receptor 2 isoform 2

    See identical proteins and their annotated locations for NP_001186144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (2).
    Source sequence(s)
    AC074044, AC092892
    Consensus CDS
    CCDS56267.1
    Related
    ENSP00000418413.1, ENST00000488794.6
    Conserved Domains (1) summary
    cl11960
    Location:135 → 203
    Ig; Immunoglobulin domain

  3. NM_001370552.3 → NP_001357481.1  cell surface glycoprotein CD200 receptor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (2).
    Source sequence(s)
    AC074044, AC092892
    Consensus CDS
    CCDS56267.1
    Conserved Domains (1) summary
    cl11960
    Location:135 → 203
    Ig; Immunoglobulin domain

RNA

  1. NR_178042.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant (1, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068275

  2. NR_178043.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, non-coding) uses the same exon combination as variant (2, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068275

  3. NR_178044.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, non-coding) uses the same exon combination as variant (3, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068275

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    112815711..112846864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    115536646..115567808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q8B3.2 GenPept UniProtKB/Swiss-Prot:Q6Q8B3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous