U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF860 zinc finger protein 860 [ Homo sapiens (human) ]

Gene ID: 344787, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF860provided by HGNC
Official Full Name
zinc finger protein 860provided by HGNC
Primary source
HGNC:HGNC:34513
See related
Ensembl:ENSG00000197385 AllianceGenome:HGNC:34513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 1.1), prostate (RPKM 0.9) and 21 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF860 in Genome Data Viewer
Location:
3p23-p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (31981750..32006443)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (31984716..32009928)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32023242..32033215)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 10 Neighboring gene OSBPL10 antisense RNA 1 Neighboring gene zinc finger protein 587 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:31938297-31938798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:31987818-31988420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:31988421-31989022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14164 Neighboring gene small nucleolar RNA SNORA25 Neighboring gene ribosomal protein L21 pseudogene 40

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bioinformatic analysis of the prognostic value of ZNF860 in recurrence-free survival and its potential regulative network in gastric cancer. Pan HX, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30767193
  2. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. Shaffer JR, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347629, Free PMC Article
  3. The DNA sequence, annotation and analysis of human chromosome 3. Muzny DM, et al. Nature, 2006 Apr 27. PMID 16641997
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Clone Names

  • FLJ60236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 860

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137674.3 → NP_001131146.2  zinc finger protein 860

    See identical proteins and their annotated locations for NP_001131146.2

    Status: VALIDATED

    Source sequence(s)
    AC108485, AK294003, BQ268755
    Consensus CDS
    CCDS46784.1
    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4
    Related
    ENSP00000373274.3, ENST00000360311.5
    Conserved Domains (5) summary
    smart00349
    Location:24 → 64
    KRAB; krueppel associated box
    COG5048
    Location:284 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:288 → 308
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:24 → 63
    KRAB; KRAB box
    pfam13465
    Location:328 → 353
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    31981750..32006443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448072.1 → XP_047304028.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

  2. XM_047448074.1 → XP_047304030.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

  3. XM_047448073.1 → XP_047304029.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

RNA

  1. XR_001740138.2 RNA Sequence

  2. XR_007095674.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    31984716..32009928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346427.1 → XP_054202402.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

  2. XM_054346429.1 → XP_054202404.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

  3. XM_054346428.1 → XP_054202403.1  zinc finger protein 860 isoform X1

    UniProtKB/Swiss-Prot
    A6NHJ4, B4DFA4

RNA

  1. XR_007073404.1 RNA Sequence

  2. XR_007073405.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NHJ4.3 GenPept UniProtKB/Swiss-Prot:A6NHJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous