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CG31872 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34458, updated on 4-Apr-2024

Summary

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Official Symbol
CG31872provided by FlyBase
Primary source
FLYBASE:FBgn0051872
Locus tag
Dmel_CG31872
See related
AllianceGenome:FB:FBgn0051872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17093; CG17101; Dmel\CG31872
Summary
Enables serine hydrolase activity. Involved in multicellular organism reproduction. Located in extracellular space. Is expressed in adult head; embryonic head sensory system; sensory nervous system primordium; spermatozoon; and ventral sensory complex primordium. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
32A2-32A2; 2-43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10639931..10643539)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10639931..10643539)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45351 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using blocks of linked single nucleotide polymorphisms as highly polymorphic genetic markers for parentage analysis. Jones B, et al. Mol Ecol Resour, 2009 Mar. PMID 21564678
  2. Comparative phosphoproteomics reveal new candidates in the regulation of spermatogenesis of Drosophila melanogaster. Mao B, et al. Insect Sci, 2022 Dec. PMID 35271765
  3. Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Fiumera AC, et al. Genetics, 2005 Jan. PMID 15466425, Free PMC Article
  4. Inference of positive and negative selection on the 5' regulatory regions of Drosophila genes. Kohn MH, et al. Mol Biol Evol, 2004 Feb. PMID 14660692
  5. Nonadaptive molecular evolution of seminal fluid proteins in Drosophila. Patlar B, et al. Evolution, 2021 Aug. PMID 34184267, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sexual reproduction HEP PubMed 
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG31872-PA
CG31872-PB
NP_001285806.1
NP_723603.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10639931..10643539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298877.1 → NP_001285806.1  uncharacterized protein Dmel_CG31872, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKT1
    Conserved Domains (2) summary
    pfam04083
    Location:716 → 767
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:752 → 894
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_164937.3 → NP_723603.1  uncharacterized protein Dmel_CG31872, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723603.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKT1
    Related
    FBpp0079688
    Conserved Domains (2) summary
    pfam04083
    Location:716 → 767
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:752 → 894
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKT1 Q9VKT1

Gene LinkOut

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