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AADACL4 arylacetamide deacetylase like 4 [ Homo sapiens (human) ]

Gene ID: 343066, updated on 5-Mar-2024

Summary

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Official Symbol
AADACL4provided by HGNC
Official Full Name
arylacetamide deacetylase like 4provided by HGNC
Primary source
HGNC:HGNC:32038
See related
Ensembl:ENSG00000204518 AllianceGenome:HGNC:32038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
1p36.21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12644085..12667076)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12188232..12211227)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12704104..12727087)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear 18, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5682 Neighboring gene dehydrogenase/reductase 3 Neighboring gene microRNA 6730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12652795-12653294 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12663043-12663228 Neighboring gene Sharpr-MPRA regulatory region 11784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12677840-12678472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12678473-12679104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12679105-12679736 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12679972-12680223 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12736484-12736819 Neighboring gene uncharacterized LOC124903846 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:12763477-12764676 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:12775588-12776787 Neighboring gene arylacetamide deacetylase like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
  2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arylacetamide deacetylase-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013630.2 → NP_001013652.1  arylacetamide deacetylase-like 4

    See identical proteins and their annotated locations for NP_001013652.1

    Status: VALIDATED

    Source sequence(s)
    AC254633
    Consensus CDS
    CCDS30590.1
    UniProtKB/Swiss-Prot
    Q5VUY2
    Related
    ENSP00000365395.1, ENST00000376221.2
    Conserved Domains (2) summary
    COG0657
    Location:85 → 378
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:115 → 378
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    12644085..12667076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001153.1 → XP_016856642.1  arylacetamide deacetylase-like 4 isoform X1

    Conserved Domains (2) summary
    COG0657
    Location:3 → 212
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:14 → 212
    Abhydrolase; alpha/beta hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    12188232..12211227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336311.1 → XP_054192286.1  arylacetamide deacetylase-like 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VUY2.1 GenPept UniProtKB/Swiss-Prot:Q5VUY2

Gene LinkOut

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