U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cyp4e3 Cytochrome P450 4e3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34291, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cyp4e3provided by FlyBase
Official Full Name
Cytochrome P450 4e3provided by FlyBase
Primary source
FLYBASE:FBgn0015035
Locus tag
Dmel_CG4105
See related
AllianceGenome:FB:FBgn0015035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4e3; CG4105; cyp4e3; Cyp4E3; CYP4E3; Dmel\CG4105; P-450; P450
Summary
Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Located in endoplasmic reticulum. Is expressed in adult head; embryonic/larval fat body; embryonic/larval midgut; and epithelium. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
30C7-30C7; 2-36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9747839..9750071, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9747839..9750071, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Nckx30C Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46529 Neighboring gene zinc finger protein 30C Neighboring gene TBP-associated factor 11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Terhzaz S, et al. Insect Biochem Mol Biol, 2015 Dec. PMID 26073628, Free PMC Article
  2. Cyclophosphamide in Drosophila promotes genes and transposable elements differential expression and mitochondrial dysfunction. Stoffel TJR, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2020 Apr. PMID 31982542
  3. Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs. Muraoka Y, et al. Exp Neurol, 2018 Dec. PMID 30165075
  4. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
  5. A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Cruz C, et al. Genetics, 2009 Nov. PMID 19737745, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cytochrome P450 4e3
Names
CG4105-PA
Cyp4e3-PA
cytochrome P450
cytochrome P450-4e3
NP_523527.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9747839..9750071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078803.2 → NP_523527.1  cytochrome P450 4e3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24128, Q9VL92
    UniProtKB/TrEMBL
    A8E6N0
    Related
    FBpp0079515
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 468
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VL92.1 Q9VL92

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous