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C16orf96 chromosome 16 open reading frame 96 [ Homo sapiens (human) ]

Gene ID: 342346, updated on 5-Mar-2024

Summary

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Official Symbol
C16orf96provided by HGNC
Official Full Name
chromosome 16 open reading frame 96provided by HGNC
Primary source
HGNC:HGNC:40031
See related
Ensembl:ENSG00000205832 AllianceGenome:HGNC:40031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 4.7), brain (RPKM 0.3) and 1 other tissue See more
Orthologs
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Genomic context

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See C16orf96 in Genome Data Viewer
Location:
16p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4538601..4600758)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4568062..4630216)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4588602..4650759)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4516031-4516532 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4526195-4526696 Neighboring gene uncharacterized LOC124903636 Neighboring gene NmrA like redox sensor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4543888-4544077 Neighboring gene heme oxygenase 2 Neighboring gene Sharpr-MPRA regulatory region 9698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4563218-4563745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4563746-4564272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4564273-4564800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4571909-4572773 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4579080-4579732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4579733-4580384 Neighboring gene cell death inducing p53 target 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4604203-4604813 Neighboring gene SUB1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4635152-4635652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4642470-4643270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4644073-4644872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4661103-4661738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7157 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4665101-4665673 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4665674-4666245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7158 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4674556-4675086 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:4675087-4675616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4676147-4676675 Neighboring gene UBA like domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 850, pseudogene Neighboring gene mahogunin ring finger 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression. Howley BV, et al. Oncogene, 2022 Mar. PMID 35102251, Free PMC Article
  2. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
  3. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
  4. Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. Feng X, et al. Sci Adv, 2022 May 13. PMID 35559673, Free PMC Article
  5. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Yadav L, et al. Cell Syst, 2017 Apr 26. PMID 28330616

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
uncharacterized protein C16orf96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145011.2 → NP_001138483.1  uncharacterized protein C16orf96

    See identical proteins and their annotated locations for NP_001138483.1

    Status: VALIDATED

    Source sequence(s)
    AC023830
    Consensus CDS
    CCDS53986.1
    UniProtKB/Swiss-Prot
    A6NNT2, C9JH24
    Related
    ENSP00000415027.3, ENST00000444310.5
    Conserved Domains (4) summary
    PHA03247
    Location:286 → 436
    PHA03247; large tegument protein UL36; Provisional
    NF033178
    Location:476 → 543
    auto_BigA; autotransporter adhesin BigA
    pfam16043
    Location:744 → 919
    DUF4795; Domain of unknown function (DUF4795)
    cl17169
    Location:248 → 284
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001387219.1 → NP_001374148.1  uncharacterized protein C16orf96

    Status: VALIDATED

    Source sequence(s)
    AC023830
    Consensus CDS
    CCDS53986.1
    UniProtKB/Swiss-Prot
    A6NNT2, C9JH24
    Conserved Domains (4) summary
    PHA03247
    Location:286 → 436
    PHA03247; large tegument protein UL36; Provisional
    NF033178
    Location:476 → 543
    auto_BigA; autotransporter adhesin BigA
    pfam16043
    Location:744 → 919
    DUF4795; Domain of unknown function (DUF4795)
    cl17169
    Location:248 → 284
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    4538601..4600758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434053.1 → XP_047290009.1  uncharacterized protein C16orf96 isoform X3

  2. XM_005255301.4 → XP_005255358.1  uncharacterized protein C16orf96 isoform X2

    Conserved Domains (4) summary
    TIGR02953
    Location:501 → 552
    penta_MxKDx; pentapeptide MXKDX repeat protein
    pfam10630
    Location:285 → 440
    DUF2476; Protein of unknown function (DUF2476)
    pfam16043
    Location:730 → 864
    DUF4795; Domain of unknown function (DUF4795)
    cl17169
    Location:248 → 284
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_005255298.4 → XP_005255355.1  uncharacterized protein C16orf96 isoform X1

    Conserved Domains (4) summary
    TIGR02953
    Location:481 → 532
    penta_MxKDx; pentapeptide MXKDX repeat protein
    pfam10630
    Location:285 → 440
    DUF2476; Protein of unknown function (DUF2476)
    pfam16043
    Location:710 → 899
    DUF4795; Domain of unknown function (DUF4795)
    cl17169
    Location:248 → 284
    RRM_SF; RNA recognition motif (RRM) superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    4568062..4630216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380217.1 → XP_054236192.1  uncharacterized protein C16orf96 isoform X4

  2. XM_054380218.1 → XP_054236193.1  uncharacterized protein C16orf96 isoform X4

  3. XM_054380221.1 → XP_054236196.1  uncharacterized protein C16orf96 isoform X3

  4. XM_054380220.1 → XP_054236195.1  uncharacterized protein C16orf96 isoform X2

  5. XM_054380219.1 → XP_054236194.1  uncharacterized protein C16orf96 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NNT2.3 GenPept UniProtKB/Swiss-Prot:A6NNT2

Gene LinkOut

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Chemical Information
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Research Materials
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