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LManIII Lysosomal alpha-mannosidase III [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34203, updated on 10-May-2024

Summary

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Official Symbol
LManIIIprovided by FlyBase
Official Full Name
Lysosomal alpha-mannosidase IIIprovided by FlyBase
Primary source
FLYBASE:FBgn0032066
Locus tag
Dmel_CG9463
See related
AllianceGenome:FB:FBgn0032066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9463; Dmel\CG9463
Summary
Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
29F1-29F1; 2-34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8765273..8768710, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8765273..8768710, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lysosomal alpha-mannosidase IV Neighboring gene Lysosomal alpha-mannosidase V

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of class I and II α-mannosidases from Drosophila melanogaster. Nemčovičová I, et al. Glycoconj J, 2013 Dec. PMID 23979800
  2. Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. Yang H, et al. BMC Genomics, 2017 May 18. PMID 28521739, Free PMC Article
  3. Larvae of Drosophila melanogaster exhibit transcriptional activation of immune response pathways and antimicrobial peptides during recovery from supercooling stress. Štětina T, et al. Insect Biochem Mol Biol, 2019 Feb. PMID 30660665
  4. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
  5. Asymmetric sequence divergence of duplicate genes. Conant GC, et al. Genome Res, 2003 Sep. PMID 12952876, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysosomal alpha-mannosidase III
Names
CG9463-PA
CG9463-PB
LManIII-PA
LManIII-PB
NP_001285762.1
NP_609250.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8765273..8768710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298833.1 → NP_001285762.1  lysosomal alpha-mannosidase III, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285762.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYY1, Q9VLI2
    Conserved Domains (3) summary
    cd10810
    Location:37 → 311
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    pfam07748
    Location:603 → 998
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    pfam09261
    Location:358 → 433
    Alpha-mann_mid; Alpha mannosidase, middle domain

  2. NM_135406.4 → NP_609250.2  lysosomal alpha-mannosidase III, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609250.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYY1, Q9VLI2
    Related
    FBpp0079346
    Conserved Domains (3) summary
    cd10810
    Location:37 → 311
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    pfam07748
    Location:603 → 998
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    pfam09261
    Location:358 → 433
    Alpha-mann_mid; Alpha mannosidase, middle domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYY1 Q8SYY1
Q9VLI2 Q9VLI2

Gene LinkOut

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