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POU2AF2 POU class 2 homeobox associating factor 2 [ Homo sapiens (human) ]

Gene ID: 341032, updated on 13-Mar-2024

Summary

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Official Symbol
POU2AF2provided by HGNC
Official Full Name
POU class 2 homeobox associating factor 2provided by HGNC
Primary source
HGNC:HGNC:30527
See related
Ensembl:ENSG00000150750 MIM:620671; AllianceGenome:HGNC:30527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCAT1; OCA-T1; C11orf53
Expression
Biased expression in testis (RPKM 1.3), colon (RPKM 0.7) and 13 other tissues See more
Orthologs
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Genomic context

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Location:
11q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111245725..111286401)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111255953..111296584)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111116450..111157126)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723966 Neighboring gene long intergenic non-protein coding RNA 2550 Neighboring gene ribosomal protein S17 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3894 Neighboring gene colorectal cancer associated 1 Neighboring gene POU class 2 homeobox associating factor 3 Neighboring gene uncharacterized LOC105369491

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. POU2AF2/C11orf53 functions as a coactivator of POU2F3 by maintaining chromatin accessibility and enhancer activity. Szczepanski AP, et al. Sci Adv, 2022 Oct 7. PMID 36197978, Free PMC Article
  2. OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Wu XS, et al. Nature, 2022 Jul. PMID 35576971, Free PMC Article
  3. Open reading frames associated with cancer in the dark matter of the human genome. Delgado AP, et al. Cancer Genomics Proteomics, 2014 Jul-Aug. PMID 25048349
  4. The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis. Funato Y, et al. Dev Cell, 2020 Nov 23. PMID 32918875
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. COLCA2 (POU2AF3) and likely C11orf53 (POU2AF2) function as transcriptional co-activators of POU2F3 in tuft cell-like small cell lung cancer.
    Title: Selective regulation of tuft cell-like small cell lung cancer by novel transcriptional co-activators C11orf53 and COLCA2.
  2. OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.
    Title: OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC50104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables POU domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
POU domain class 2-associating factor 2
Names
oct coactivator from tuft cells 1
protein POU2AF2
uncharacterized protein C11orf53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198498.3 → NP_940900.2  POU domain class 2-associating factor 2

    Status: VALIDATED

    Source sequence(s)
    AP002448
    Consensus CDS
    CCDS31674.2
    UniProtKB/Swiss-Prot
    A0A1C7CYV6, Q8IXP5
    Related
    ENSP00000280325.6, ENST00000280325.7
    Conserved Domains (1) summary
    pfam17721
    Location:55 → 288
    DUF5566; Family of unknown function (DUF5566)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    111245725..111286401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542804.3 → XP_011541106.2  POU domain class 2-associating factor 2 isoform X1

    Related
    ENSP00000489630.1, ENST00000637637.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    111255953..111296584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368654.1 → XP_054224629.1  POU domain class 2-associating factor 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXP5.2 GenPept UniProtKB/Swiss-Prot:Q8IXP5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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