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Spn28B Serpin 28B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34035, updated on 27-Mar-2024

Summary

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Official Symbol
Spn28Bprovided by FlyBase
Official Full Name
Serpin 28Bprovided by FlyBase
Primary source
FLYBASE:FBgn0083141
Locus tag
Dmel_CG6717
See related
AllianceGenome:FB:FBgn0083141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6717; Dmel\CG6717; Spn7
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in multicellular organism reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); lung disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINC1 (serpin family C member 1) and SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
28B3-28B3; 2-27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7581924..7583333)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7581924..7583333)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rap GTPase activating protein 1 Neighboring gene long non-coding RNA:CR44082 Neighboring gene long non-coding RNA:CR46063 Neighboring gene long non-coding RNA:CR46535 Neighboring gene long non-coding RNA:CR45370

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Richer MJ, et al. Proc Natl Acad Sci U S A, 2004 Jul 20. PMID 15247425, Free PMC Article
  2. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416
  3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
  4. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
  5. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin 28B
Names
CG6717-PA
CG6717-PB
Spn28B-PA
Spn28B-PB
serine protease inhibitor 7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7581924..7583333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135284.3 → NP_609128.2  serpin 28B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609128.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8F4V2, Q9VLZ8
    Conserved Domains (1) summary
    cd00172
    Location:17 → 373
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_001273280.1 → NP_001260209.1  serpin 28B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260209.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8F4V2, Q9VLZ8
    Conserved Domains (1) summary
    cd00172
    Location:17 → 373
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLZ8 Q9VLZ8

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