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Ziz Zizimin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34030, updated on 27-Mar-2024

Summary

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Official Symbol
Zizprovided by FlyBase
Official Full Name
Ziziminprovided by FlyBase
Primary source
FLYBASE:FBgn0260486
Locus tag
Dmel_CG42533
See related
AllianceGenome:FB:FBgn0260486
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH71439; CG15819; CG42533; CG6630; Dm ziz; Dmel\CG42533
Old locus tag
Dmel_CG15819; Dmel_CG6630
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in compound eye development. Is expressed in adult head and spermatozoon. Orthologous to human DOCK10 (dedicator of cytokinesis 10); DOCK11 (dedicator of cytokinesis 11); and DOCK9 (dedicator of cytokinesis 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Ziz in Genome Data Viewer
Location:
28A1-28A4; 2-27 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7472513..7496307, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7472513..7496307, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 28b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rap GTPase activating protein 1 Neighboring gene Odorant-binding protein 28a Neighboring gene long non-coding RNA:CR44082

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila DOCK Family Protein Zizimin Involves in Pigment Cell Differentiation in Pupal Retinae. Ozasa F, et al. Cell Struct Funct, 2017 Aug 26. PMID 28701658
  2. CZH proteins: a new family of Rho-GEFs. Meller N, et al. J Cell Sci, 2005 Nov 1. PMID 16254241
  3. The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42. Sampson CJ, et al. Dev Comp Immunol, 2012 Sep. PMID 22634526
  4. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
  5. The Genetic Architecture of Ovariole Number in Drosophila melanogaster: Genes with Major, Quantitative, and Pleiotropic Effects. Lobell AS, et al. G3 (Bethesda), 2017 Jul 5. PMID 28550012, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
zizimin
Names
CG42533-PB
CG42533-PC
CG42533-PD
CG42533-PE
CG42533-PG
CG42533-PH
CG42533-PI
CG42533-PJ
CG42533-PK
Dm zizimin
Ziz-PB
Ziz-PC
Ziz-PD
Ziz-PE
Ziz-PG
Ziz-PH
Ziz-PI
Ziz-PJ
Ziz-PK
zizimin ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7472513..7496307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273277.1 → NP_001260206.1  zizimin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260206.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF31
    Conserved Domains (5) summary
    cd08697
    Location:793 → 981
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:278 → 405
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 393
    PH; PH domain
    pfam06920
    Location:1748 → 2230
    DHR-2; Dock homology region 2
    pfam11878
    Location:54 → 81
    DUF3398; Domain of unknown function (DUF3398)

  2. NM_001273271.1 → NP_001260200.1  zizimin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCG3
    Conserved Domains (5) summary
    cd08697
    Location:793 → 981
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:278 → 405
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 393
    PH; PH domain
    pfam06920
    Location:1751 → 2233
    DHR-2; Dock homology region 2
    pfam11878
    Location:54 → 81
    DUF3398; Domain of unknown function (DUF3398)

  3. NM_135281.4 → NP_609125.4  zizimin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609125.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VM04
    Conserved Domains (5) summary
    cd08697
    Location:793 → 981
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:278 → 405
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 393
    PH; PH domain
    pfam06920
    Location:1751 → 2233
    DHR-2; Dock homology region 2
    pfam11878
    Location:54 → 81
    DUF3398; Domain of unknown function (DUF3398)

  4. NM_001273275.1 → NP_001260204.1  zizimin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCU9
    Conserved Domains (5) summary
    cd08697
    Location:793 → 982
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:278 → 405
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 393
    PH; PH domain
    pfam06920
    Location:1749 → 2231
    DHR-2; Dock homology region 2
    pfam11878
    Location:54 → 81
    DUF3398; Domain of unknown function (DUF3398)

  5. NM_001273273.1 → NP_001260202.1  zizimin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB64
    Conserved Domains (5) summary
    cd08697
    Location:793 → 982
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:278 → 405
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:283 → 393
    PH; PH domain
    pfam06920
    Location:1752 → 2234
    DHR-2; Dock homology region 2
    pfam11878
    Location:54 → 81
    DUF3398; Domain of unknown function (DUF3398)

  6. NM_001273278.1 → NP_001260207.1  zizimin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB65
    Conserved Domains (5) summary
    cd08697
    Location:807 → 995
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:292 → 419
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:297 → 407
    PH; PH domain
    pfam06920
    Location:1762 → 2244
    DHR-2; Dock homology region 2
    pfam11878
    Location:68 → 95
    DUF3398; Domain of unknown function (DUF3398)

  7. NM_001273274.1 → NP_001260203.1  zizimin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCA8
    Conserved Domains (5) summary
    cd08697
    Location:807 → 995
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:292 → 419
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:297 → 407
    PH; PH domain
    pfam06920
    Location:1765 → 2247
    DHR-2; Dock homology region 2
    pfam11878
    Location:68 → 95
    DUF3398; Domain of unknown function (DUF3398)

  8. NM_001273272.1 → NP_001260201.1  zizimin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF26
    Conserved Domains (5) summary
    cd08697
    Location:807 → 996
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:292 → 419
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:297 → 407
    PH; PH domain
    pfam06920
    Location:1763 → 2245
    DHR-2; Dock homology region 2
    pfam11878
    Location:68 → 95
    DUF3398; Domain of unknown function (DUF3398)

  9. NM_001273276.1 → NP_001260205.1  zizimin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260205.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCG7
    Conserved Domains (5) summary
    cd08697
    Location:807 → 996
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd13267
    Location:292 → 419
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:297 → 407
    PH; PH domain
    pfam06920
    Location:1766 → 2248
    DHR-2; Dock homology region 2
    pfam11878
    Location:68 → 95
    DUF3398; Domain of unknown function (DUF3398)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PB64 M9PB64
M9PB65 M9PB65
M9PCA8 M9PCA8
M9PCG3 M9PCG3
M9PCG7 M9PCG7
M9PCU9 M9PCU9
M9PF26 M9PF26
M9PF31 M9PF31
Q8MYS5 Q8MYS5
Q9VM04 Q9VM04

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