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TREML1 triggering receptor expressed on myeloid cells like 1 [ Homo sapiens (human) ]

Gene ID: 340205, updated on 5-Mar-2024

Summary

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Official Symbol
TREML1provided by HGNC
Official Full Name
triggering receptor expressed on myeloid cells like 1provided by HGNC
Primary source
HGNC:HGNC:20434
See related
Ensembl:ENSG00000161911 MIM:609714; AllianceGenome:HGNC:20434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
Summary
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Expression
Biased expression in bone marrow (RPKM 1.9), lymph node (RPKM 1.7) and 10 other tissues See more
Orthologs
all
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Genomic context

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Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41149260..41155403, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40977812..40983997, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41116998..41122087, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17173 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene MPRA-validated peak5800 silencer Neighboring gene ADCY10 pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17174 Neighboring gene uncharacterized LOC107986595

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) reveals platelet activation in preeclampsia. He L, et al. Platelets, 2022 Nov 17. PMID 35348422
  2. TLT-1 Promotes Platelet-Monocyte Aggregate Formation to Induce IL-10-Producing B Cells in Tuberculosis. Wang M, et al. J Immunol, 2022 Apr 1. PMID 35277419
  3. Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality. Lin JC, et al. Burns, 2021 Sep. PMID 33958244
  4. Defining the TLT-1 interactome from resting and activated human platelets. Schmoker AM, et al. J Proteomics, 2020 Mar 20. PMID 31923473, Free PMC Article
  5. Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain. Esponda OL, et al. Clin Appl Thromb Hemost, 2015 Jan. PMID 25147325, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.
    Title: Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.
  2. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) reveals platelet activation in preeclampsia.
    Title: Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) reveals platelet activation in preeclampsia.
  3. TLT-1 Promotes Platelet-Monocyte Aggregate Formation to Induce IL-10-Producing B Cells in Tuberculosis.
    Title: TLT-1 Promotes Platelet-Monocyte Aggregate Formation to Induce IL-10-Producing B Cells in Tuberculosis.
  4. Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality.
    Title: Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality.
  5. Defining the TLT-1 interactome from resting and activated human platelets.
    Title: Defining the TLT-1 interactome from resting and activated human platelets.
  6. P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study.
    Title: P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study.
  7. binding with macrophage membrane receptor, FcR1, initiates inflammatory signals in macrophages
    Title: Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease.
  8. we show that gene expression profiling of RUNX1 knock-down or mutated MK provides a suitable approach to identify novel RUNX1 targets, among which downregulation of TREML1 and ITGA2 clearly contribute to the platelet phenotype of familial platelet disorder with predisposition to AML.
    Title: Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia.
  9. TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.
    Title: TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.
  10. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels.
    Title: A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of triggering receptor expressed on myeloid cells-like 1 (TREML1) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in platelet alpha granule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
trem-like transcript 1 protein
Names
triggering receptor expressed on myeloid cells-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271807.1 → NP_001258736.1  trem-like transcript 1 protein isoform b precursor

    See identical proteins and their annotated locations for NP_001258736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL133404, AY358357, BQ023322, DW009745
    Consensus CDS
    CCDS64421.1
    UniProtKB/Swiss-Prot
    Q86YW5
    Related
    ENSP00000362219.4, ENST00000373127.8
    Conserved Domains (1) summary
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

  2. NM_001271808.1 → NP_001258737.1  trem-like transcript 1 protein isoform c

    See identical proteins and their annotated locations for NP_001258737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
    Source sequence(s)
    AL133404, AY358357, BC100946, BQ023322, DW009745
    Consensus CDS
    CCDS64420.1
    UniProtKB/Swiss-Prot
    Q86YW5
    Related
    ENSP00000400405.1, ENST00000437044.2

  3. NM_178174.4 → NP_835468.1  trem-like transcript 1 protein isoform a precursor

    See identical proteins and their annotated locations for NP_835468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL133404
    Consensus CDS
    CCDS4851.1
    UniProtKB/Swiss-Prot
    Q496B3, Q86YW5, Q8IWY1, Q8IWY2
    Related
    ENSP00000402855.2, ENST00000426005.7
    Conserved Domains (1) summary
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    41149260..41155403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010825.2 → XP_016866314.1  trem-like transcript 1 protein isoform X3

  2. XM_017010822.2 → XP_016866311.1  trem-like transcript 1 protein isoform X1

  3. XM_017010823.2 → XP_016866312.1  trem-like transcript 1 protein isoform X2

    UniProtKB/Swiss-Prot
    Q496B3, Q86YW5, Q8IWY1, Q8IWY2
    Conserved Domains (1) summary
    cl11960
    Location:25 → 113
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    40977812..40983997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355322.1 → XP_054211297.1  trem-like transcript 1 protein isoform X3

  2. XM_054355320.1 → XP_054211295.1  trem-like transcript 1 protein isoform X1

  3. XM_054355321.1 → XP_054211296.1  trem-like transcript 1 protein isoform X2

    UniProtKB/Swiss-Prot
    Q496B3, Q86YW5, Q8IWY1, Q8IWY2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YW5.2 GenPept UniProtKB/Swiss-Prot:Q86YW5

Gene LinkOut

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