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CCDC158 coiled-coil domain containing 158 [ Homo sapiens (human) ]

Gene ID: 339965, updated on 5-Mar-2024

Summary

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Official Symbol
CCDC158provided by HGNC
Official Full Name
coiled-coil domain containing 158provided by HGNC
Primary source
HGNC:HGNC:26374
See related
Ensembl:ENSG00000163749 AllianceGenome:HGNC:26374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 16.4) See more
Orthologs
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Genomic context

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See CCDC158 in Genome Data Viewer
Location:
4q21.1
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (76313039..76421869, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (79653758..79762651, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (77234192..77342294, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377286 Neighboring gene FAM47E-STBD1 readthrough Neighboring gene family with sequence similarity 47 member E Neighboring gene NFE2L2 motif-containing MPRA enhancer 290 Neighboring gene starch binding domain 1 Neighboring gene RNA, U6 small nuclear 1000, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:77301727-77302231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:77309531-77310030 Neighboring gene sorting nexin 5 pseudogene 1 Neighboring gene small nucleolar RNA SNORD50 Neighboring gene ribosomal protein L36a pseudogene 18 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:77379997-77381196 Neighboring gene shroom family member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:77398744-77399474 Neighboring gene RNA, U6 small nuclear 145, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:77479863-77480494 Neighboring gene microRNA 4450

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. New loci associated with kidney function and chronic kidney disease. Köttgen A, et al. Nat Genet, 2010 May. PMID 20383146, Free PMC Article
  2. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Xu XR, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752456, Free PMC Article
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Vandamme J, et al. Mol Cell Proteomics, 2011 Apr. PMID 21282530, Free PMC Article
  4. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25770, MGC35086

General protein information

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Preferred Names
coiled-coil domain-containing protein 158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042784.1 → NP_001036249.1  coiled-coil domain-containing protein 158 isoform 2

    See identical proteins and their annotated locations for NP_001036249.1

    Status: VALIDATED

    Source sequence(s)
    BC035224, BC086869
    Consensus CDS
    CCDS43242.1
    UniProtKB/Swiss-Prot
    Q5M9N0, Q8IYQ1, Q8N7D4, Q8N7E3
    Related
    ENSP00000373566.2, ENST00000388914.7
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1113
    CCDC158; Coiled-coil domain-containing protein 158

  2. NM_001394954.1 → NP_001381883.1  coiled-coil domain-containing protein 158 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC034139, AC096743
    Consensus CDS
    CCDS93551.1
    UniProtKB/TrEMBL
    A0A804HIY6
    Related
    ENSP00000507278.1, ENST00000682701.1
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    76313039..76421869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531911.2 → XP_011530213.1  coiled-coil domain-containing protein 158 isoform X1

    See identical proteins and their annotated locations for XP_011530213.1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

  2. XM_011531917.2 → XP_011530219.1  coiled-coil domain-containing protein 158 isoform X4

    See identical proteins and their annotated locations for XP_011530219.1

    Conserved Domains (1) summary
    pfam15921
    Location:12 → 1035
    CCDC158; Coiled-coil domain-containing protein 158

  3. XM_011531909.3 → XP_011530211.1  coiled-coil domain-containing protein 158 isoform X1

    See identical proteins and their annotated locations for XP_011530211.1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

  4. XM_011531912.3 → XP_011530214.1  coiled-coil domain-containing protein 158 isoform X1

    See identical proteins and their annotated locations for XP_011530214.1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

  5. XM_011531914.3 → XP_011530216.1  coiled-coil domain-containing protein 158 isoform X1

    See identical proteins and their annotated locations for XP_011530216.1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

  6. XM_011531915.3 → XP_011530217.1  coiled-coil domain-containing protein 158 isoform X3

    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1066
    CCDC158; Coiled-coil domain-containing protein 158

  7. XM_005262974.5 → XP_005263031.1  coiled-coil domain-containing protein 158 isoform X2

    See identical proteins and their annotated locations for XP_005263031.1

    UniProtKB/Swiss-Prot
    Q5M9N0, Q8IYQ1, Q8N7D4, Q8N7E3
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1113
    CCDC158; Coiled-coil domain-containing protein 158

  8. XM_011531908.3 → XP_011530210.1  coiled-coil domain-containing protein 158 isoform X1

    See identical proteins and their annotated locations for XP_011530210.1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

  9. XM_017008160.2 → XP_016863649.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

  10. XM_011531910.4 → XP_011530212.1  coiled-coil domain-containing protein 158 isoform X1

    See identical proteins and their annotated locations for XP_011530212.1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

  11. XM_011531913.1 → XP_011530215.1  coiled-coil domain-containing protein 158 isoform X1

    See identical proteins and their annotated locations for XP_011530215.1

    UniProtKB/TrEMBL
    A0A804HIY6
    Conserved Domains (1) summary
    pfam15921
    Location:1 → 1117
    CCDC158; Coiled-coil domain-containing protein 158

RNA

  1. XR_938729.3 RNA Sequence

  2. XR_938730.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    79653758..79762651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349915.1 → XP_054205890.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

  2. XM_054349924.1 → XP_054205899.1  coiled-coil domain-containing protein 158 isoform X4

  3. XM_054349917.1 → XP_054205892.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

  4. XM_054349919.1 → XP_054205894.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

  5. XM_054349921.1 → XP_054205896.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

  6. XM_054349923.1 → XP_054205898.1  coiled-coil domain-containing protein 158 isoform X3

  7. XM_054349922.1 → XP_054205897.1  coiled-coil domain-containing protein 158 isoform X2

    UniProtKB/Swiss-Prot
    Q5M9N0, Q8IYQ1, Q8N7D4, Q8N7E3

  8. XM_054349916.1 → XP_054205891.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

  9. XM_054349918.1 → XP_054205893.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

  10. XM_054349914.1 → XP_054205889.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

  11. XM_054349920.1 → XP_054205895.1  coiled-coil domain-containing protein 158 isoform X1

    UniProtKB/TrEMBL
    A0A804HIY6

RNA

  1. XR_008486975.1 RNA Sequence

  2. XR_008486976.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178555.3: Suppressed sequence

    Description
    NM_178555.3: This RefSeq was permanently suppressed because it has a none consensus splice site that does not have enough supporting evidence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M9N0.2 GenPept UniProtKB/Swiss-Prot:Q5M9N0

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