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ANKRD45 ankyrin repeat domain 45 [ Homo sapiens (human) ]

Gene ID: 339416, updated on 5-Mar-2024

Summary

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Official Symbol
ANKRD45provided by HGNC
Official Full Name
ankyrin repeat domain 45provided by HGNC
Primary source
HGNC:HGNC:24786
See related
Ensembl:ENSG00000183831 MIM:618712; AllianceGenome:HGNC:24786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT117
Expression
Biased expression in testis (RPKM 3.3), brain (RPKM 0.8) and 5 other tissues See more
Orthologs
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Genomic context

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Location:
1q25.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173608336..173715185, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (172966487..173073343, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173577475..173638990, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904456 Neighboring gene MPRA-validated peak459 silencer Neighboring gene Sharpr-MPRA regulatory region 4744 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173473949-173475148 Neighboring gene peroxiredoxin 6 Neighboring gene solute carrier family 9 member C2 (putative) Neighboring gene uncharacterized LOC105371619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173610829-173612028 Neighboring gene small nucleolar RNA U13 Neighboring gene testis expressed 50 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2115 Neighboring gene kelch like family member 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:173728073-173728573 Neighboring gene ribosomal protein S27 pseudogene 7 Neighboring gene RN7SK pseudogene 160

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ankrd45 Is a Novel Ankyrin Repeat Protein Required for Cell Proliferation. Kang Y, et al. Genes (Basel), 2019 Jun 16. PMID 31208154, Free PMC Article
  2. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45235, MGC161631, MGC161633

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 45
Names
cancer/testis antigen 117

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198493.3 → NP_940895.1  ankyrin repeat domain-containing protein 45

    See identical proteins and their annotated locations for NP_940895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AK127170, AL139142, BC126355
    Consensus CDS
    CCDS1309.1
    UniProtKB/Swiss-Prot
    A1A4G2, Q5TZF3, Q6ZST1
    Related
    ENSP00000331268.2, ENST00000333279.3
    Conserved Domains (3) summary
    cd00204
    Location:74 → 162
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:77 → 107
    ANK; ANK repeat [structural motif]
    cl26953
    Location:144 → 240
    HSP70; Hsp70 protein

RNA

  1. NR_158771.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139142, BX248409

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    173608336..173715185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001123.2 → XP_016856612.1  ankyrin repeat domain-containing protein 45 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:94 → 182
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:97 → 150
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:97 → 127
    ANK; ANK repeat [structural motif]

  2. XM_047419195.1 → XP_047275151.1  ankyrin repeat domain-containing protein 45 isoform X1

  3. XM_011509470.3 → XP_011507772.1  ankyrin repeat domain-containing protein 45 isoform X2

    See identical proteins and their annotated locations for XP_011507772.1

    UniProtKB/Swiss-Prot
    A1A4G2, Q5TZF3, Q6ZST1
    Conserved Domains (3) summary
    cd00204
    Location:74 → 162
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:77 → 107
    ANK; ANK repeat [structural motif]
    cl26953
    Location:144 → 240
    HSP70; Hsp70 protein

  4. XM_047419198.1 → XP_047275154.1  ankyrin repeat domain-containing protein 45 isoform X2

    UniProtKB/Swiss-Prot
    A1A4G2, Q5TZF3, Q6ZST1

  5. XM_024446627.2 → XP_024302395.1  ankyrin repeat domain-containing protein 45 isoform X2

    UniProtKB/Swiss-Prot
    A1A4G2, Q5TZF3, Q6ZST1
    Conserved Domains (3) summary
    cd00204
    Location:74 → 162
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:77 → 107
    ANK; ANK repeat [structural motif]
    cl26953
    Location:144 → 240
    HSP70; Hsp70 protein

  6. XM_047419206.1 → XP_047275162.1  ankyrin repeat domain-containing protein 45 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    172966487..173073343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336244.1 → XP_054192219.1  ankyrin repeat domain-containing protein 45 isoform X1

  2. XM_054336245.1 → XP_054192220.1  ankyrin repeat domain-containing protein 45 isoform X1

  3. XM_054336248.1 → XP_054192223.1  ankyrin repeat domain-containing protein 45 isoform X2

    UniProtKB/Swiss-Prot
    A1A4G2, Q5TZF3, Q6ZST1

  4. XM_054336247.1 → XP_054192222.1  ankyrin repeat domain-containing protein 45 isoform X2

    UniProtKB/Swiss-Prot
    A1A4G2, Q5TZF3, Q6ZST1

  5. XM_054336246.1 → XP_054192221.1  ankyrin repeat domain-containing protein 45 isoform X2

    UniProtKB/Swiss-Prot
    A1A4G2, Q5TZF3, Q6ZST1

  6. XM_054336249.1 → XP_054192224.1  ankyrin repeat domain-containing protein 45 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TZF3.2 GenPept UniProtKB/Swiss-Prot:Q5TZF3

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