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ADAMTSL5 ADAMTS like 5 [ Homo sapiens (human) ]

Gene ID: 339366, updated on 5-Mar-2024

Summary

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Official Symbol
ADAMTSL5provided by HGNC
Official Full Name
ADAMTS like 5provided by HGNC
Primary source
HGNC:HGNC:27912
See related
Ensembl:ENSG00000185761 AllianceGenome:HGNC:27912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THSD6
Summary
Enables heparin binding activity and microfibril binding activity. Located in extracellular region and microfibril. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in endometrium (RPKM 3.3), heart (RPKM 2.8) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1505022..1513019, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1475471..1483468, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1505021..1513018, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1482223-1482834 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9724 Neighboring gene receptor accessory protein 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1497018-1497572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1507743-1508592 Neighboring gene uncharacterized LOC124904609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9727 Neighboring gene uncharacterized LOC107985337 Neighboring gene polo like kinase 5 (inactive)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circular RNA circPFKP suppresses the proliferation and metastasis of gastric cancer cell via sponging miR-644 and regulating ADAMTSL5 expression. Kong S, et al. Bioengineered, 2022 May. PMID 35587154, Free PMC Article
  2. Melanocyte antigen triggers autoimmunity in human psoriasis. Arakawa A, et al. J Exp Med, 2015 Dec 14. PMID 26621454, Free PMC Article
  3. ADAMTSL5 and CDH11: putative epigenetic markers for therapeutic resistance in acute lymphoblastic leukemia. Abdullah M, et al. Hematology, 2017 Aug. PMID 28292214
  4. A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module. Bader HL, et al. Matrix Biol, 2012 Sep-Oct. PMID 23010571, Free PMC Article
  5. Pan-genome isolation of low abundance transcripts using SAGE tag. Kim YC, et al. FEBS Lett, 2006 Dec 11. PMID 17113583, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA circPFKP suppresses the proliferation and metastasis of gastric cancer cell via sponging miR-644 and regulating ADAMTSL5 expression.
    Title: Circular RNA circPFKP suppresses the proliferation and metastasis of gastric cancer cell via sponging miR-644 and regulating ADAMTSL5 expression.
  2. Chemoresistant B-ALL patients are associated with increased methylation in ADAMTSL5 and CDH11.
    Title: ADAMTSL5 and CDH11: putative epigenetic markers for therapeutic resistance in acute lymphoblastic leukemia.
  3. ADAMTSL5 could have a role in modulating microfibril functions.
    Title: A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microfibril binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microfibril IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADAMTS-like protein 5
Names
ADAMTSL-5
thrombospondin type-1 domain-containing protein 6
thrombospondin, type I, domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367197.1 → NP_001354126.1  ADAMTS-like protein 5 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC027307, AW167554, BX951496
    UniProtKB/Swiss-Prot
    B4DXK7, Q6ZMM2, Q8IW95
    Conserved Domains (4) summary
    smart00209
    Location:48 → 97
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:375 → 476
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:206 → 311
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:106 → 174
    ADAM_CR; ADAM cysteine-rich

  2. NM_213604.3 → NP_998769.2  ADAMTS-like protein 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK131571, BC040620, BC119796, DR979736
    Consensus CDS
    CCDS12071.1
    UniProtKB/TrEMBL
    X6R4H8
    Related
    ENSP00000327608.3, ENST00000330475.9
    Conserved Domains (4) summary
    smart00209
    Location:38 → 87
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:365 → 466
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:196 → 301
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:96 → 164
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1505022..1513019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438758.1 → XP_047294714.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  2. XM_047438757.1 → XP_047294713.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  3. XM_047438756.1 → XP_047294712.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  4. XM_047438755.1 → XP_047294711.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  5. XM_011527961.2 → XP_011526263.1  ADAMTS-like protein 5 isoform X1

    Conserved Domains (4) summary
    smart00209
    Location:48 → 97
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:379 → 480
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:206 → 315
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:106 → 174
    ADAM_CR; ADAM cysteine-rich

  6. XM_017026745.2 → XP_016882234.1  ADAMTS-like protein 5 isoform X3

    UniProtKB/TrEMBL
    X6R4H8
    Conserved Domains (4) summary
    smart00209
    Location:38 → 87
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:365 → 466
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:196 → 301
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:96 → 164
    ADAM_CR; ADAM cysteine-rich

  7. XM_047438751.1 → XP_047294707.1  ADAMTS-like protein 5 isoform X2

  8. XM_047438754.1 → XP_047294710.1  ADAMTS-like protein 5 isoform X4

  9. XM_047438752.1 → XP_047294708.1  ADAMTS-like protein 5 isoform X4

  10. XM_047438753.1 → XP_047294709.1  ADAMTS-like protein 5 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1475471..1483468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320836.1 → XP_054176811.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  2. XM_054320835.1 → XP_054176810.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  3. XM_054320834.1 → XP_054176809.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  4. XM_054320833.1 → XP_054176808.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6

  5. XM_054320827.1 → XP_054176802.1  ADAMTS-like protein 5 isoform X1

  6. XM_054320829.1 → XP_054176804.1  ADAMTS-like protein 5 isoform X3

    UniProtKB/TrEMBL
    X6R4H8

  7. XM_054320828.1 → XP_054176803.1  ADAMTS-like protein 5 isoform X2

  8. XM_054320832.1 → XP_054176807.1  ADAMTS-like protein 5 isoform X4

  9. XM_054320830.1 → XP_054176805.1  ADAMTS-like protein 5 isoform X4

  10. XM_054320831.1 → XP_054176806.1  ADAMTS-like protein 5 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMM2.3 GenPept UniProtKB/Swiss-Prot:Q6ZMM2

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