U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM95 transmembrane protein 95 [ Homo sapiens (human) ]

Gene ID: 339168, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TMEM95provided by HGNC
Official Full Name
transmembrane protein 95provided by HGNC
Primary source
HGNC:HGNC:27898
See related
Ensembl:ENSG00000182896 MIM:617814; AllianceGenome:HGNC:27898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ9390
Summary
Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in sperm plasma membrane. Predicted to be integral component of membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 4.1), thyroid (RPKM 3.1) and 1 other tissue See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17p13.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7355156..7357219)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7259147..7261210)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7258475..7260538)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7239291-7240052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7240053-7240814 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8111 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258016-7258542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258543-7259069 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7269638-7269860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7283926-7284426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8114 Neighboring gene tyrosine kinase non receptor 1 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8115 Neighboring gene phospholipid scramblase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11618 Neighboring gene transmembrane protein 256

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Human sperm TMEM95 binds eggs and facilitates membrane fusion. Tang S, et al. Proc Natl Acad Sci U S A, 2022 Oct 4. PMID 36161911, Free PMC Article
  2. TMEM95 is a sperm membrane protein essential for mammalian fertilization. Lamas-Toranzo I, et al. Elife, 2020 Jun 2. PMID 32484434, Free PMC Article
  3. A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. Pausch H, et al. PLoS Genet, 2014 Jan. PMID 24391514, Free PMC Article
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human sperm TMEM95 binds eggs and facilitates membrane fusion.
    Title: Human sperm TMEM95 binds eggs and facilitates membrane fusion.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC129793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in acrosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sperm-egg fusion protein TMEM95

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320435.2 → NP_001307364.1  sperm-egg fusion protein TMEM95 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AY358218, BC040900
    Consensus CDS
    CCDS82052.1
    UniProtKB/Swiss-Prot
    Q3KNT9
    Related
    ENSP00000374632.4, ENST00000389982.8
    Conserved Domains (1) summary
    pfam15203
    Location:17 → 138
    TMEM95; TMEM95 family

  2. NM_001320436.2 → NP_001307365.1  sperm-egg fusion protein TMEM95 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC026954, BC107110
    Consensus CDS
    CCDS82051.1
    UniProtKB/Swiss-Prot
    B7WPI7, Q3KNT9, Q6UXT3, Q8IW68
    Related
    ENSP00000460828.1, ENST00000576060.6
    Conserved Domains (1) summary
    pfam15203
    Location:17 → 154
    TMEM95; TMEM95 family

  3. NM_198154.3 → NP_937797.1  sperm-egg fusion protein TMEM95 isoform 2 precursor

    See identical proteins and their annotated locations for NP_937797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC026954
    Consensus CDS
    CCDS32546.1
    UniProtKB/Swiss-Prot
    Q3KNT9
    Related
    ENSP00000331466.4, ENST00000330767.4
    Conserved Domains (1) summary
    pfam15203
    Location:17 → 162
    TMEM95; TMEM95 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7355156..7357219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024571.2 → XP_016880060.1  sperm-egg fusion protein TMEM95 isoform X1

  2. XM_017024565.2 → XP_016880054.1  sperm-egg fusion protein TMEM95 isoform X2

  3. XM_017024566.2 → XP_016880055.1  sperm-egg fusion protein TMEM95 isoform X3

  4. XM_017024567.2 → XP_016880056.1  sperm-egg fusion protein TMEM95 isoform X4

  5. XM_017024568.2 → XP_016880057.1  sperm-egg fusion protein TMEM95 isoform X5

    UniProtKB/Swiss-Prot
    B7WPI7, Q3KNT9, Q6UXT3, Q8IW68
    Conserved Domains (1) summary
    pfam15203
    Location:17 → 154
    TMEM95; TMEM95 family

  6. XM_017024569.2 → XP_016880058.1  sperm-egg fusion protein TMEM95 isoform X5

    UniProtKB/Swiss-Prot
    B7WPI7, Q3KNT9, Q6UXT3, Q8IW68
    Conserved Domains (1) summary
    pfam15203
    Location:17 → 154
    TMEM95; TMEM95 family

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p14 PATCHES

    Range
    113521..115584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332654.1 → XP_054188629.1  sperm-egg fusion protein TMEM95 isoform X1

  2. XM_054332655.1 → XP_054188630.1  sperm-egg fusion protein TMEM95 isoform X2

  3. XM_054332656.1 → XP_054188631.1  sperm-egg fusion protein TMEM95 isoform X3

  4. XM_054332657.1 → XP_054188632.1  sperm-egg fusion protein TMEM95 isoform X4

  5. XM_054332659.1 → XP_054188634.1  sperm-egg fusion protein TMEM95 isoform X5

    UniProtKB/Swiss-Prot
    B7WPI7, Q3KNT9, Q6UXT3, Q8IW68

  6. XM_054332658.1 → XP_054188633.1  sperm-egg fusion protein TMEM95 isoform X5

    UniProtKB/Swiss-Prot
    B7WPI7, Q3KNT9, Q6UXT3, Q8IW68

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7259147..7261210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315929.1 → XP_054171904.1  sperm-egg fusion protein TMEM95 isoform X1

  2. XM_054315930.1 → XP_054171905.1  sperm-egg fusion protein TMEM95 isoform X2

  3. XM_054315931.1 → XP_054171906.1  sperm-egg fusion protein TMEM95 isoform X3

  4. XM_054315932.1 → XP_054171907.1  sperm-egg fusion protein TMEM95 isoform X4

  5. XM_054315934.1 → XP_054171909.1  sperm-egg fusion protein TMEM95 isoform X5

    UniProtKB/Swiss-Prot
    B7WPI7, Q3KNT9, Q6UXT3, Q8IW68

  6. XM_054315933.1 → XP_054171908.1  sperm-egg fusion protein TMEM95 isoform X5

    UniProtKB/Swiss-Prot
    B7WPI7, Q3KNT9, Q6UXT3, Q8IW68
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KNT9.1 GenPept UniProtKB/Swiss-Prot:Q3KNT9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous