mmy mummy [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mmyprovided by FlyBase
Official Full Name: mummyprovided by FlyBase
Primary source: FLYBASE:FBgn0259749
Locus tag: Dmel_CG9535
See related: AllianceGenome:FB:FBgn0259749
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0140519.242; BcDNA:LD24639; cao; CG9535; cys; cyst; cystic; Dmel\CG9535; l(2)k13717b; LD44264; mum; UAP1
Summary: Enables UDP-N-acetylglucosamine diphosphorylase activity. Involved in several processes, including chitin-based cuticle development; morphogenesis of embryonic epithelium; and nervous system development. Is expressed in several structures, including adult head; early extended germ band embryo; embryonic/larval midgut; and embryonic/larval tracheal system. Orthologous to human UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1) and UAP1L1 (UDP-N-acetylglucosamine pyrophosphorylase 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6468538..6473904, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6468538..6473904, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Mmy is required for Slit secretion and for maintaining Robo abundance and distribution in the developing nervous system in Drosophila.
Title: The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons.
mmy is essential for multiple developmental events in Drosophila.
Title: Mummy, A UDP-N-acetylglucosamine pyrophosphorylase, modulates DPP signaling in the embryonic epidermis of Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine diphosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine diphosphorylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables uridylyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based embryonic cuticle biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle chitin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic epithelial tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Names: CG9535-PA; CG9535-PB; CG9535-PD; UDP-GlcNAc pyrophosphorylase; UDP-N-acetylglucosamine diphosphorylase; UDP-N-acetylglucosamine pyrophosphorylase; cabrio; cystic; mmy-PA; mmy-PB; mmy-PD

NP_001285673.1

NP_609032.1

NP_723183.1

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The following sections contain reference sequences that belong to a specific genome build. Explain