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Tig Tiggrin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33896, updated on 4-Apr-2024

Summary

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Official Symbol
Tigprovided by FlyBase
Official Full Name
Tiggrinprovided by FlyBase
Primary source
FLYBASE:FBgn0011722
Locus tag
Dmel_CG11527
See related
AllianceGenome:FB:FBgn0011722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11527; CT36389; Dmel\CG11527; tig; TIG
Summary
Enables integrin binding activity. Involved in cell adhesion mediated by integrin; cell morphogenesis involved in differentiation; and regulation of cell adhesion mediated by integrin. Located in basement membrane. Is expressed in several structures, including circulatory system; fat body; metameric furrow; muscle system; and spermatozoon. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
26D1-26D1; 2-20 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6415179..6423310, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6415179..6423310, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dpr-interacting protein epsilon Neighboring gene Neprilysin-like 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fic domain-containing protein Neighboring gene Acyl-CoA oxidase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The matrix protein Tiggrin regulates plasmatocyte maturation in Drosophila larva. Zhang CU, et al. Development, 2017 Jul 1. PMID 28526755, Free PMC Article
  2. Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity. Bunch TA, et al. J Biol Chem, 2006 Feb 24. PMID 16371365
  3. Disruption of C-terminal cytoplasmic domain of betaPS integrin subunit has dominant negative properties in developing Drosophila. Jannuzi AL, et al. Mol Biol Cell, 2002 Apr. PMID 11950944, Free PMC Article
  4. Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila alpha PS2 beta PS integrins. Fogerty FJ, et al. Development, 1994 Jul. PMID 7924982
  5. Evidence of Swim secretion and association with extracellular matrix in the Drosophila embryo. Kaltezioti V, et al. Int J Dev Biol, 2022. PMID 34881800

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wee1 inhibits plasmatocyte maturation through upregulation of Tiggrin transcription.
    Title: The matrix protein Tiggrin regulates plasmatocyte maturation in Drosophila larva.
  2. the glycosyltransferase, pgant3, specifically modulates integrin-mediated cell adhesion by influencing the secretion and localization of the integrin ligand, Tiggrin
    Title: An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell adhesion mediated by integrin IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
tiggrin
Names
CG11527-PA
CG11527-PB
Tig-PA
Tig-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6415179..6423310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298741.1 → NP_001285670.1  tiggrin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285670.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23984, Q6NR23, Q9VMD9
    UniProtKB/TrEMBL
    X2JDD7
    Conserved Domains (2) summary
    COG1196
    Location:1021 → 1370
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:416 → 1194
    CCDC158; Coiled-coil domain-containing protein 158

  2. NM_057685.4 → NP_477033.1  tiggrin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477033.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23984, Q6NR23, Q9VMD9
    UniProtKB/TrEMBL
    X2JDD7
    Related
    FBpp0078905
    Conserved Domains (2) summary
    COG1196
    Location:1021 → 1370
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:416 → 1194
    CCDC158; Coiled-coil domain-containing protein 158
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMD9.2 Q9VMD9
X2JDD7 X2JDD7

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