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FFAR4 free fatty acid receptor 4 [ Homo sapiens (human) ]

Gene ID: 338557, updated on 11-Apr-2024

Summary

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Official Symbol
FFAR4provided by HGNC
Official Full Name
free fatty acid receptor 4provided by HGNC
Primary source
HGNC:HGNC:19061
See related
Ensembl:ENSG00000186188 MIM:609044; AllianceGenome:HGNC:19061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GT01; PGR4; OB10Q; BMIQ10; GPR120; GPR129; O3FAR1
Summary
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Biased expression in colon (RPKM 6.8), fat (RPKM 2.6) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
10q23.33
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93566665..93590072)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94446619..94470024)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95326422..95349829)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3496 Neighboring gene centrosomal protein 55 Neighboring gene RNA, 5S ribosomal pseudogene 323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:95315968-95316468 Neighboring gene uncharacterized LOC105378436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:95325824-95326662 Neighboring gene uncharacterized LOC124902485 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:95341272-95341477 Neighboring gene retinol binding protein 4 Neighboring gene phosphodiesterase 6C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells. Karmokar PF, et al. Biochem Pharmacol, 2023 Jul. PMID 37201877
  2. Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4. Duah M, et al. J Nutr Biochem, 2023 Feb. PMID 36402250
  3. GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma. Sun X, et al. Pancreatology, 2022 Sep. PMID 35717305
  4. Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children. Codoñer-Alejos A, et al. J Pediatr Gastroenterol Nutr, 2022 Apr 1. PMID 35703949
  5. Teadenol A in microbial fermented tea acts as a novel ligand on GPR120 to increase GLP-1 secretion. Nagasawa T , et al. Food Funct, 2020 Dec 1. PMID 33185223

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism.
    Title: FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism.
  2. GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease.
    Title: GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease.
  3. Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.
    Title: Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.
  4. Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.
    Title: Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.
  5. Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.
    Title: Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.
  6. Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
    Title: Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
  7. GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma.
    Title: GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma.
  8. Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children.
    Title: Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children.
  9. Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.
    Title: Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.
  10. GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.
    Title: GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.
Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Body mass index quantitative trait locus 10
MedGen: C2675659 OMIM: 607514 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study of circulating retinol levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC119984, DKFZp686F0824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of chemical stimulus involved in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
  
involved_in ghrelin secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of somatostatin secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in white fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
free fatty acid receptor 4
Names
G-protein coupled receptor 120
G-protein coupled receptor 129
G-protein coupled receptor GT01
G-protein coupled receptor PGR4
Obesity, susceptibility to, on chromosome 10q
omega-3 fatty acid receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032670.1 RefSeqGene

    Range
    5001..28408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195755.2 → NP_001182684.1  free fatty acid receptor 4 isoform GPR120-S

    See identical proteins and their annotated locations for NP_001182684.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (GPR120-S) lacking a 16 aa protein segment compared to isoform GPR120-L.
    Source sequence(s)
    AI469384, AI732606, AK301525, AL356214, BC101175, BM757151, DA986310
    Consensus CDS
    CCDS55720.1
    UniProtKB/Swiss-Prot
    Q495H1, Q5NUL3, Q5VY25, Q5VY26, Q7Z605, Q86SM7
    UniProtKB/TrEMBL
    B4DWG6
    Related
    ENSP00000360536.5, ENST00000371481.9
    Conserved Domains (1) summary
    cd00637
    Location:43 → 321
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

  2. NM_181745.4 → NP_859529.2  free fatty acid receptor 4 isoform GPR120-L

    See identical proteins and their annotated locations for NP_859529.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (GPR120-L).
    Source sequence(s)
    AI469384, AI732606, AK301525, AL356214, AY288417, BC101175, BM757151, DA986310
    Consensus CDS
    CCDS31248.1
    UniProtKB/TrEMBL
    B4DWG6
    Related
    ENSP00000360538.4, ENST00000371483.8
    Conserved Domains (1) summary
    pfam00001
    Location:73 → 337
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    93566665..93590072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539746.4 → XP_011538048.1  free fatty acid receptor 4 isoform X1

    UniProtKB/TrEMBL
    S4R3L2
    Conserved Domains (1) summary
    pfam00001
    Location:73 → 233
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    94446619..94470024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365713.1 → XP_054221688.1  free fatty acid receptor 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NUL3.3 GenPept UniProtKB/Swiss-Prot:Q5NUL3

Gene LinkOut

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