U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RAB7B RAB7B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 338382, updated on 30-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
RAB7Bprovided by HGNC
Official Full Name
RAB7B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:30513
See related
Ensembl:ENSG00000276600 AllianceGenome:HGNC:30513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB7
Summary
Predicted to enable GTP binding activity and GTPase activity. Involved in late endosome to Golgi transport; positive regulation of megakaryocyte differentiation; and regulation of gene expression. Located in cytoplasmic vesicle; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 15.7), gall bladder (RPKM 6.5) and 20 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RAB7B in Genome Data Viewer
Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205976740..206003395, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205240788..205267388, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205889161-205889692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205889693-205890223 Neighboring gene solute carrier family 26 member 9 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205897002-205897542 Neighboring gene SLC26A9 and RAB7B antisense RNA 1 Neighboring gene uncharacterized LOC103021295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206328947-206329447 Neighboring gene cathepsin E Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206299039-206299540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2395 Neighboring gene uncharacterized LOC105372857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2396 Neighboring gene Sharpr-MPRA regulatory region 5780 Neighboring gene regulator of hemoglobinization and erythroid cell expansion

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dynamics of Rab7b-dependent transport of sorting receptors. Progida C, et al. Traffic, 2012 Sep. PMID 22708738
  2. Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells. Yang M, et al. Biochem Biophys Res Commun, 2004 Jun 4. PMID 15144907
  3. Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34. Cain RJ, et al. mBio, 2023 Feb 28. PMID 36656016, Free PMC Article
  4. Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. Vestre K, et al. J Cell Sci, 2021 Sep 15. PMID 34494097, Free PMC Article
  5. Rab7b participation on the TLR4 (Toll-like receptor) endocytic pathway in Shiga toxin-associated Hemolytic Uremic Syndrome (HUS). Lafalla Manzano AF, et al. Cytokine, 2019 Sep. PMID 31153054

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34.
    Title: Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34.
  2. Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton.
    Title: Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton.
  3. Rab7b participation on the TLR4 (Toll-like receptor) endocytic pathway in Shiga toxin-associated Hemolytic Uremic Syndrome (HUS).
    Title: Rab7b participation on the TLR4 (Toll-like receptor) endocytic pathway in Shiga toxin-associated Hemolytic Uremic Syndrome (HUS).
  4. TBC1D5 is a GAP for Rab7b in the control of endosomal transport to the trans-Golgi.
    Title: TBC1D5 controls the GTPase cycle of Rab7b.
  5. study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B
    Title: Rab7b modulates autophagic flux by interacting with Atg4B.
  6. Authors determined the effects of T. suis soluble products (SPs) on Toll-like receptor-4 (TLR4)- In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling
    Title: Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells.
  7. Rab9a and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex.
    Title: Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection.
  8. Rab7b is required for sortilin transport from endosomes to the TGN.
    Title: Dynamics of Rab7b-dependent transport of sorting receptors.
  9. Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB and promoting IL-6 production.
    Title: Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association.
  10. Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network.
    Title: Rab7b controls trafficking from endosomes to the TGN.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed
gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
gag HIV-1 Gag mainly remains in endosomes and co-localizes with endosomal protein Rab7 in the cycloheximide-treated cells PubMed
capsid gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC9726, MGC16212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of toll-like receptor 9 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane TAS
Traceable Author Statement
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ras-related protein Rab-7b
Names
Ras-related protein Rab-7
NP_001157994.1
NP_001291768.1
NP_796377.3
XP_006711351.1
XP_054192218.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164522.3 → NP_001157994.1  ras-related protein Rab-7b isoform a

    See identical proteins and their annotated locations for NP_001157994.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AUXG01000006
    Consensus CDS
    CCDS73011.1
    UniProtKB/Swiss-Prot
    Q96AH8
    Related
    ENSP00000482499.1, ENST00000617070.5
    Conserved Domains (1) summary
    cd00154
    Location:9 → 169
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

  2. NM_001304839.2 → NP_001291768.1  ras-related protein Rab-7b isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AUXG01000006
    Consensus CDS
    CCDS76258.1
    UniProtKB/TrEMBL
    A0A096LP44
    Related
    ENSP00000485386.1, ENST00000623893.1
    Conserved Domains (1) summary
    cd00154
    Location:9 → 132
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

  3. NM_177403.6 → NP_796377.3  ras-related protein Rab-7b isoform a

    See identical proteins and their annotated locations for NP_796377.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AUXG01000006
    Consensus CDS
    CCDS73011.1
    UniProtKB/Swiss-Prot
    Q96AH8
    Related
    ENSP00000479762.1, ENST00000617991.4
    Conserved Domains (1) summary
    cd00154
    Location:9 → 169
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    205976740..206003395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711288.5 → XP_006711351.1  ras-related protein Rab-7b isoform X1

    Conserved Domains (2) summary
    smart00175
    Location:9 → 174
    RAB; Rab subfamily of small GTPases
    cd00154
    Location:9 → 169
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    205240788..205267388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336243.1 → XP_054192218.1  ras-related protein Rab-7b isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96AH8.1 GenPept UniProtKB/Swiss-Prot:Q96AH8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous