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Map3k9 mitogen-activated protein kinase kinase kinase 9 [ Mus musculus (house mouse) ]

Gene ID: 338372, updated on 11-Apr-2024

Summary

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Official Symbol
Map3k9provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 9provided by MGI
Primary source
MGI:MGI:2449952
See related
Ensembl:ENSMUSG00000042724 AllianceGenome:MGI:2449952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlk1; Prke1; E130314H24Rik
Summary
Predicted to enable JUN kinase kinase kinase activity. Predicted to be involved in cell death; positive regulation of apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within apoptotic process and phosphorylation. Orthologous to human MAP3K9 (mitogen-activated protein kinase kinase kinase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 6.1), CNS E18 (RPKM 6.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D1; 12 37.91 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81761724..81828010, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81714950..81781170, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32677 Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene ragulator complex protein LAMTOR2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4034 Neighboring gene STARR-seq mESC enhancer starr_32680 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:82893600-82893709 Neighboring gene predicted gene, 30706 Neighboring gene STARR-seq mESC enhancer starr_32681 Neighboring gene pecanex 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:83072406-83072559 Neighboring gene STARR-seq mESC enhancer starr_32682

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Bisson N, et al. Cell Cycle, 2008 Apr 1. PMID 18414056
  2. Modulation of SRF-dependent gene expression by association of SPT16 with MKL1. Kihara T, et al. Exp Cell Res, 2008 Feb 1. PMID 18036521
  3. MAP3Ks as central regulators of cell fate during development. Craig EA, et al. Dev Dyn, 2008 Nov. PMID 18855897
  4. Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Wajapeyee N, et al. Genes Dev, 2013 Oct 15. PMID 24105743, Free PMC Article
  5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9.
    Title: MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9.
  2. There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse.
    Title: Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.
  3. These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex.
    Title: Modulation of SRF-dependent gene expression by association of SPT16 with MKL1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 9
NP_001167578.1
NP_796369.2
XP_006516099.1
XP_006516100.1
XP_017170611.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174107.1 → NP_001167578.1  mitogen-activated protein kinase kinase kinase 9 isoform 1

    See identical proteins and their annotated locations for NP_001167578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125351, AK053843, AK155677
    Consensus CDS
    CCDS49104.1
    UniProtKB/Swiss-Prot
    E9QLZ4, Q3U1V8, Q8BIG8
    Related
    ENSMUSP00000041819.8, ENSMUST00000035987.9
    Conserved Domains (3) summary
    smart00219
    Location:137 → 396
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:49 → 106
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14145
    Location:130 → 399
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

  2. NM_177395.5 → NP_796369.2  mitogen-activated protein kinase kinase kinase 9 isoform 2

    See identical proteins and their annotated locations for NP_796369.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AC125351, AK053843, AK155677
    UniProtKB/Swiss-Prot
    Q3U1V8
    Related
    ENSMUST00000223292.2
    Conserved Domains (3) summary
    cd12059
    Location:49 → 106
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    smart00221
    Location:137 → 396
    STYKc; Protein kinase; unclassified specificity
    cd14145
    Location:130 → 399
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    81761724..81828010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315122.3 → XP_017170611.1  mitogen-activated protein kinase kinase kinase 9 isoform X1

    Conserved Domains (2) summary
    cd12059
    Location:49 → 106
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14145
    Location:130 → 399
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

  2. XM_006516036.5 → XP_006516099.1  mitogen-activated protein kinase kinase kinase 9 isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VKX4
    Related
    ENSMUSP00000152201.2, ENSMUST00000222322.2
    Conserved Domains (2) summary
    cd12059
    Location:49 → 106
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14145
    Location:130 → 399
    STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

  3. XM_006516037.4 → XP_006516100.1  mitogen-activated protein kinase kinase kinase 9 isoform X3

    UniProtKB/TrEMBL
    Q8K2L2
    Conserved Domains (3) summary
    PHA03247
    Location:547 → 808
    PHA03247; large tegument protein UL36; Provisional
    cl21453
    Location:27 → 162
    PKc_like; Protein Kinases, catalytic domain
    cl27170
    Location:183 → 265
    DUF460; Protein of unknown function (DUF460)

RNA

  1. XR_004937523.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1V8.2 GenPept UniProtKB/Swiss-Prot:Q3U1V8

Gene LinkOut

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