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Endov endonuclease V [ Mus musculus (house mouse) ]

Gene ID: 338371, updated on 18-Apr-2024

Summary

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Official Symbol
Endovprovided by MGI
Official Full Name
endonuclease Vprovided by MGI
Primary source
MGI:MGI:2444688
See related
Ensembl:ENSMUSG00000039850 AllianceGenome:MGI:2444688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730011L01Rik
Summary
Enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters and magnesium ion binding activity. Involved in DNA repair. Predicted to be located in cytoplasmic stress granule. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ENDOV (endonuclease V). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 5.4), limb E14.5 (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 83.8 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119382173..119402291)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119491322..119511465)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 1932 Neighboring gene ring finger protein 213 Neighboring gene STARR-positive B cell enhancer ABC_E3043 Neighboring gene RIKEN cDNA A930037H05 gene Neighboring gene STARR-positive B cell enhancer ABC_E7112 Neighboring gene STARR-positive B cell enhancer ABC_E8475 Neighboring gene predicted gene, 39484 Neighboring gene neuronal pentraxin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Kong XY, et al. Nucleic Acids Res, 2020 May 7. PMID 32083667, Free PMC Article
  2. Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease. Nawaz MS, et al. Sci Rep, 2016 Apr 25. PMID 27108838, Free PMC Article
  3. Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V. Moe A, et al. Nucleic Acids Res, 2003 Jul 15. PMID 12853604, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data suggest that EndoV is involved in the development of hepatocellular carcinoma in mice.
    Title: Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
  2. Mouse Endonuclease V shares substrate preferences with human EndoV by catalyzing cleavage at inosines in RNA and being inert towards inosines in DNA.
    Title: Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity, producing 5'-phosphomonoesters IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity, producing 5'-phosphomonoesters ISO
Inferred from Sequence Orthology
more info
  
enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endonuclease V
Names
novel endonuclease V protein
putative endonuclease FLJ39025 homolog
NP_001158108.1
NP_001388988.1
NP_001388989.1
NP_796368.1
XP_011247389.1
XP_036012680.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164636.1 → NP_001158108.1  endonuclease V isoform 1

    See identical proteins and their annotated locations for NP_001158108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK084233, AL645911, BC056486
    Consensus CDS
    CCDS48999.1
    UniProtKB/Swiss-Prot
    B1ATE4, Q3TCQ4, Q8C3Y1, Q8C9A2
    Related
    ENSMUSP00000101851.3, ENSMUST00000106244.9
    Conserved Domains (1) summary
    cd06559
    Location:17 → 245
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

  2. NM_001402059.1 → NP_001388988.1  endonuclease V isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645911

  3. NM_001402060.1 → NP_001388989.1  endonuclease V isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645911

  4. NM_177394.3 → NP_796368.1  endonuclease V isoform 2

    See identical proteins and their annotated locations for NP_796368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate 5' splice pattern and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL645911, BC056486, BY266398
    Consensus CDS
    CCDS25718.1
    UniProtKB/Swiss-Prot
    Q8C9A2
    Related
    ENSMUSP00000132755.2, ENSMUST00000106245.9
    Conserved Domains (1) summary
    cd06559
    Location:7 → 162
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

RNA

  1. NR_174994.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645911
    Related
    ENSMUST00000143817.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119382173..119402291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249087.3 → XP_011247389.1  endonuclease V isoform X4

    Conserved Domains (1) summary
    cd06559
    Location:17 → 245
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

  2. XM_036156787.1 → XP_036012680.1  endonuclease V isoform X1

    Conserved Domains (1) summary
    cd06559
    Location:17 → 245
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

RNA

  1. XR_004936981.1 RNA Sequence

  2. XR_388482.4 RNA Sequence

  3. XR_004936983.1 RNA Sequence

  4. XR_004936982.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C9A2.2 GenPept UniProtKB/Swiss-Prot:Q8C9A2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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