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Supv3l1 suppressor of var1, 3-like 1 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 338359, updated on 21-Apr-2024

Summary

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Official Symbol
Supv3l1provided by MGI
Official Full Name
suppressor of var1, 3-like 1 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2441711
See related
Ensembl:ENSMUSG00000020079 AllianceGenome:MGI:2441711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330443E10Rik
Summary
Predicted to enable helicase activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrion. Is expressed in several structures, including brain; early embryo; extraembryonic component; sensory organ; and skin. Orthologous to human SUPV3L1 (Suv3 like RNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 5.0), CNS E11.5 (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 32.4 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62265000..62287294, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62429221..62451515, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hexokinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61803279-61803470 Neighboring gene hexokinase 1, opposite strand Neighboring gene hexokinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26882 Neighboring gene predicted gene, 30322 Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912425-61912612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912686-61912869 Neighboring gene VPS26 retromer complex component A Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830 Neighboring gene STARR-seq mESC enhancer starr_26886 Neighboring gene STARR-positive B cell enhancer ABC_E6862 Neighboring gene STARR-positive B cell enhancer ABC_E6863 Neighboring gene STARR-positive B cell enhancer ABC_E6864 Neighboring gene serglycin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Chen PL, et al. Oncogene, 2013 Feb 28. PMID 22562243, Free PMC Article
  2. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Paul E, et al. Transgenic Res, 2010 Aug. PMID 19937380, Free PMC Article
  3. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Paul E, et al. Mamm Genome, 2009 Feb. PMID 19145458, Free PMC Article
  4. Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. Pereira M, et al. Mech Ageing Dev, 2007 Nov-Dec. PMID 17961633
  5. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Fisher CL, et al. Nucleic Acids Res, 2017 Dec 1. PMID 28981838, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUV3 Helicase and Mitochondrial Homeostasis.
    Title: SUV3 Helicase and Mitochondrial Homeostasis.
  2. Spatial and temporal aspects of Supv3L1 promoter activity.
    Title: Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse.
  3. Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes.
    Title: Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
  4. Mice homozygous for Supv3L1 mutation die in utero before midgestation.
    Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (9)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial RNA surveillance ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial mRNA surveillance ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial ncRNA surveillance ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of mitochondrial degradosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial degradosome ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase SUPV3L1, mitochondrial
Names
SUV3-like protein 1
suppressor of var1 3-like protein 1
NP_001346735.1
NP_852088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359806.1 → NP_001346735.1  ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK031911, AK143755, AW049139, BB859685
    Conserved Domains (2) summary
    cd00079
    Location:112 → 247
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam12513
    Location:387 → 433
    SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

  2. NM_181423.3 → NP_852088.1  ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_852088.1

    Status: VALIDATED

    Source sequence(s)
    AK143755, AW049139, BB859685, BC049796
    Consensus CDS
    CCDS35920.1
    UniProtKB/Swiss-Prot
    Q50HX5, Q80YD1
    Related
    ENSMUSP00000020273.10, ENSMUST00000020273.16
    Conserved Domains (3) summary
    smart00487
    Location:187 → 353
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:351 → 486
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam12513
    Location:626 → 672
    SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62265000..62287294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003948720.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YD1.1 GenPept UniProtKB/Swiss-Prot:Q80YD1

Gene LinkOut

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