Akap17b A kinase anchor protein 17B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap17bprovided by MGI
Official Full Name: A kinase anchor protein 17Bprovided by MGI
Primary source: MGI:MGI:2443758
See related: Ensembl:ENSMUSG00000059708 AllianceGenome:MGI:2443758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Talia; PRKA17B; Sfrs17b; Srsf17b; AKAP-17B; B230333C21Rik; C230056F04Rik
Summary: Predicted to enable protein kinase A binding activity. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol and nuclear speck. Predicted to be part of spliceosomal complex. Is expressed in several structures, including extraembryonic component; heart; liver; lung; and spleen. Orthologous to several human genes including AKAP17A (A-kinase anchoring protein 17A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 2.2), frontal lobe adult (RPKM 1.8) and 21 other tissues See more
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Genomic context

Location:: X A3.3; X 21.01 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (35871832..35909021, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (36608173..36645465, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The previously undescribed gene Talia is expressed specifically in the distal-most part of the extraembryonic ectoderm, adjacent to the epiblast, and is therefore potential candidates for regulating early patterning events.
Title: Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Markers

Sfrs17b (e-PCR), detects polymorphism
- UniSTS:478986

RH124622 (e-PCR)
- UniSTS:161444

Sfrs17b (e-PCR), detects polymorphism
- UniSTS:502713

Sfrs17b (e-PCR), detects polymorphism
- UniSTS:502714

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A-kinase anchor protein 17B

Names: A kinase (PRKA) anchor protein 17B; protein Talia; protein kinase A-anchoring protein 17B; serine/arginine-rich splicing factor 17B; splicing factor, arginine/serine-rich 17b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081956.2 → NP_001075425.1 A-kinase anchor protein 17B isoform 1

See identical proteins and their annotated locations for NP_001075425.1

Status: VALIDATED

Source sequence(s)

AL450397

Consensus CDS

CCDS40924.1

UniProtKB/Swiss-Prot

A2A3V1, B0QZD2, Q0P534, Q8BR01, Q8C6P6

Related

ENSMUSP00000052042.7, ENSMUST00000051906.13

Conserved Domains (1) summary

cd12264
Location:143 → 262

RRM_AKAP17A; RNA recognition motif found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins
NM_001419768.1 → NP_001406697.1 A-kinase anchor protein 17B isoform 1

Status: VALIDATED

Source sequence(s)

AL450397

UniProtKB/Swiss-Prot

A2A3V1, B0QZD2, Q0P534, Q8BR01, Q8C6P6
NM_001419769.1 → NP_001406698.1 A-kinase anchor protein 17B isoform 2

Status: VALIDATED

Source sequence(s)

AL450397