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Cyp4ac1 Cytochrome P450 4ac1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33754, updated on 29-Dec-2023

Summary

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Official Symbol
Cyp4ac1provided by FlyBase
Official Full Name
Cytochrome P450 4ac1provided by FlyBase
Primary source
FLYBASE:FBgn0031693
Locus tag
Dmel_CG14032
See related
AllianceGenome:FB:FBgn0031693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4ac1; CG14032; cyp4ac1; Cyp4AC1; CYP4ac1; Dmel\CG14032
Summary
Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Is expressed in adult head. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Cyp4ac1 in Genome Data Viewer
Location:
25D2-25D2; 2-16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5264001..5265899)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5264001..5265899)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thickveins Neighboring gene pseudo Neighboring gene long non-coding RNA:CR44744 Neighboring gene Cytochrome P450 4ac2 Neighboring gene Cytochrome P450 4ac3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Davies L, et al. Insect Biochem Mol Biol, 2006 Oct. PMID 17027846
  2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
  3. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Zhang D, et al. Chromosoma, 2011 Feb. PMID 20857302
  4. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article
  5. Buffering of Genetic Regulatory Networks in Drosophila melanogaster. Fear JM, et al. Genetics, 2016 Jul. PMID 27194752, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4ac1
Names
CG14032-PA
Cyp4ac1-PA
NP_608916.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5264001..5265899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135072.2 → NP_608916.1  cytochrome P450 4ac1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608916.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMS9
    Related
    FBpp0078701, FBtr0079066
    Conserved Domains (1) summary
    pfam00067
    Location:86 → 504
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMS9.1 Q9VMS9

Gene LinkOut

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