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Duox Dual oxidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33477, updated on 27-Mar-2024

Summary

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Official Symbol
Duoxprovided by FlyBase
Official Full Name
Dual oxidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0283531
Locus tag
Dmel_CG3131
See related
AllianceGenome:FB:FBgn0283531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3131; Cy; dduox; dDuox; Dmel\CG3131; duox; duOx; DuoX; DUOX; l(2)23Bb
Summary
Enables peroxidase activity. Involved in several processes, including adult chitin-based cuticle development; adult chitin-containing cuticle pigmentation; and imaginal disc-derived wing morphogenesis. Located in endomembrane system. Is expressed in adult head and embryonic/larval fat body. Used to study primary bacterial infectious disease. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX1 (dual oxidase 1) and DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
23B2-23B3; 2-7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2815970..2830248, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2815970..2830248, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene dawdle Neighboring gene uncharacterized protein Neighboring gene Glucose-6-Phosphatase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 23B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microbiota aggravates the pathogenesis of Drosophila acutely exposed to vehicle exhaust. Li Y, et al. Heliyon, 2022 Sep. PMID 36060467, Free PMC Article
  2. Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila Gut. Kim EK, et al. Cell Host Microbe, 2020 Mar 11. PMID 32078802
  3. Suppression of the Drosophila Curly mutation by fluorescent light. Pavelka J, et al. Hereditas, 1996. PMID 8782435
  4. The effective lethal phase of the curly mutant in Drosophila melanogaster. Kidwell JF. J Hered, 1972 Mar-Apr. PMID 4624174
  5. On neurogenetic relations in Drosophila melanogaster. Chiarodo A, et al. J Exp Zool, 1971 Nov. PMID 4255937

See all (198) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Duox and Jak/Stat signalling influence disease tolerance in Drosophila during Pseudomonas entomophila infection.
    Title: Duox and Jak/Stat signalling influence disease tolerance in Drosophila during Pseudomonas entomophila infection.
  2. Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
    Title: Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts.
  3. our results propose that the uracil/Duox pathway promotes bacteria expulsion from the gut through the HOCl-sensitive receptor, TRPA1(A)10b, thereby minimizing the chances that bacteria adapt to survive host defense systems.
    Title: TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway.
  4. wound-induced calcium flash activates DUOX
    Title: Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release.
  5. One gene required to activate epidermal wound reporters encodes Dual oxidase, an enzyme that produces hydrogen peroxide.
    Title: Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila.
  6. dDuox plays important roles in the stabilization of the cuticle structure of the wings.
    Title: Essential role of Duox in stabilization of Drosophila wing.
  7. the Galphaq-PLCbeta-Ca(2+)-DUOX-ROS signaling pathway acts as a bona fide first line of defense that enables gut epithelia to dynamically control yeast during the Drosophila life cycle
    Title: Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD(P)H oxidase H2O2-forming activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide-generating NADPH oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adult chitin-containing cuticle pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual oxidase
Names
CG3131-PB
CG3131-PC
Duox-PB
Duox-PC
NADPH dual oxidase
curly
NP_001259968.1
NP_608715.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2815970..2830248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273039.1 → NP_001259968.1  dual oxidase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259968.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6AWK1, Q9VQH2
    UniProtKB/TrEMBL
    D0Z752, M9PCF1
    Conserved Domains (6) summary
    cd06186
    Location:1265 → 1536
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:72 → 625
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:860 → 921
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1084 → 1217
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:70 → 580
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:899 → 965
    EF-hand_7; EF-hand domain pair

  2. NM_134871.3 → NP_608715.2  dual oxidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608715.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6AWK1, Q9VQH2
    UniProtKB/TrEMBL
    D0Z752, M9PCF1
    Conserved Domains (6) summary
    cd06186
    Location:1265 → 1536
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:72 → 625
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:860 → 921
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1084 → 1217
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:70 → 580
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:899 → 965
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCF1 M9PCF1
Q9VQH2.2 Q9VQH2

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